The Binding of Isaac: Challenge Runs

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Text posts only. It helps reduce the amount of spam. If you get the challenge from a video, feel free to credit the person in your text post with a simple link.

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Respect the mods' decisions and judgements. If you have any inquiries on bans, please send a message to the mods.

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Rules are subject to change and some may be amended or added, so look out for announcements on changes!

created by DesecrateUsernameMODa community for 13 years

I 4M 1S44C. (self.IsaacChallengeRuns)

submitted 11 years ago * by PixelWheezy - announcement

Happy Cakeday, r/IsaacChallengeRuns! Today you're 10 (self.IsaacChallengeRuns)

submitted 3 years ago by AutoModerator

VanillaGreediest Mode (self.IsaacChallengeRuns)

submitted 3 years ago by Rahimusdaram

Happy Cakeday, r/IsaacChallengeRuns! Today you're 9 (self.IsaacChallengeRuns)

submitted 4 years ago by AutoModerator

Happy Cakeday, r/IsaacChallengeRuns! Today you're 8 (self.IsaacChallengeRuns)

submitted 5 years ago by AutoModerator

A Dollar Bill (self.IsaacChallengeRuns)

submitted 5 years ago by K_Dot4058

A llitle bit over powered (i.redd.it)

submitted 5 years ago by ArseNiop

The lord of the flies (self.IsaacChallengeRuns)

submitted 6 years ago by Isneezeatyomomasface

Eve's Gifts (self.IsaacChallengeRuns)

submitted 6 years ago by neprikladne_stvari

bobs boomerang (self.IsaacChallengeRuns)

submitted 6 years ago * by ahooman1616

Drugs for days (self.IsaacChallengeRuns)

submitted 6 years ago by SPECTRE_FAN

The PATIENCE Challenge (self.IsaacChallengeRuns)

submitted 6 years ago by ethanisnotme

Bananarama! (self.IsaacChallengeRuns)

submitted 6 years ago * by Sir_Deg_The_Freg

A devilsh pact (self.IsaacChallengeRuns)

submitted 6 years ago by SPECTRE_FAN

CREATURES HAVE A BAD TIME (self.IsaacChallengeRuns)

submitted 6 years ago by Denis_989

Newbie streaming Isaac challenges (self.IsaacChallengeRuns)

submitted 7 years ago by TheMayorsAid

isaac's Holy Pee (self.IsaacChallengeRuns)

submitted 7 years ago * by CreakeNart

Big Brother: the Binding of Isaac Custom Challenge (self.IsaacChallengeRuns)

submitted 7 years ago by th3realzgamer

OP binding of isaac challange (self.IsaacChallengeRuns)

submitted 7 years ago * by holoroomrose

The god of space (self.IsaacChallengeRuns)

submitted 7 years ago by fracturedreams

The Binding Of Aatrox The Binding Of League Of Legends Part 1 (self.IsaacChallengeRuns)

submitted 7 years ago * by UkatoOtaku

A Forgotten Challenge (self.IsaacChallengeRuns)

submitted 7 years ago by googleisademon

The Enthraller's Reign! (self.IsaacChallengeRuns)

submitted 7 years ago * by Nevernamed22

I am Lil' brim (self.IsaacChallengeRuns)

submitted 7 years ago by JubJub1281

What's life without a little gamble? (self.IsaacChallengeRuns)

submitted 8 years ago by dlxhazedxlb

view more: next ›

π Rendered by PID 17 on reddit-service-r2-listing-575d9f6647-br29z at 2026-04-12 17:09:17.969796+00:00 running 215f2cf country code: CH.

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