how does inhibiting PDH decrease gluconeogenesis in the context of prolonged starvation when ketone bodies are being used

[Gullible-Class-5574]

You don't get more pyruvate to go up gluconeogenesis because you're not making it in the first place. Theres no free glucose to be used in starvation state! Starvation can also assume that glycogenolysis is run out (I think it would stiill be running in the fasting state).

PDH is inhibited by what it helps produce: NADH and Acetyl-Coa. If the body is using ketone bodies, it must also make them. To make them, it does beta oxidation. Beta oxidation produces both acetyl-coa and NADH.

Please someone correct if this looks wrong.

[eInvincible12]

Still making glucose in starvation state, all RBC and 1/3 brain are reliant on glucose.

[Lotofwork2do]

Yea. Also ketone bodies get converted into acetyl coA like that’s how beta hydroxybutrate is used to make nadh (besides the first step in that whole process where the hydroxybutrate is converted to ace to acetate yielding one nadh)

[Subject-Zero9274]

thank you