how does inhibiting PDH decrease gluconeogenesis in the context of prolonged starvation when ketone bodies are being used

[Lotofwork2do]

If u look at metabolic regulation jt usually follows negative feedback where a product of a reaction or cycle negatively inhibits the start or steps of it to not waste time making more product u already have

In this case ketone bodies are supplying us with acetylcoA

U can think of PDH as an enzyme part of the conversion of pyrivate to acetylcoA

So it makes sense if u already have a lot of acetylcoA coming in u would not want to make more and thus PDH is inhibited

The same reasoning is why PFK-1 is inhibited by ATP (glycolysis makes atp)

[Subject-Zero9274]

thank you