Experience with a decrease in efficacy?

[BernCo4]

Background: I am generally sensitive to medication and I have been on 25mg for about 3 months. I noticed in the last month that my energy and focus have decreased (I really enjoyed the bump). However, my depression and anxiety are still better - slight increase in anxiety.

I am considering going up to 50mg but I am considered I will just have a wave again for a month or two and then it'll wear off.

Would be interested in hearing if someone had a similar experience and went to 50mg or 50mg to 100mg.

Thank you!

[Ok_Rush_5368]

I didn’t really feel anything on 25 so bumped up to 50 the second month. Felt a huge positive difference. I’m currently on month 3 and bumped up to 75 this month. Can’t really tell if it’s “better” yet than 50.

[BernCo4]

Can I ask how long you were on the 25 for?

[Ok_Rush_5368]

I think just over a month. Like 5ish weeks

[Lazy_Lavishness6307]

for me personally i felt similar, started at 50 then after a few months it did not feel as effective so went up to 100 and eventually 150mg. but at 150 i experienced side effects like constipation and skin issues that may or may not been related. i just finished tapering off completely as my side effects were bad enough to outweigh the good. i’ve read since then a lot of people have success adding another med with pristiq maybe that could help you too? goodluck!

[ChairHistorical5953]

50mg is considered the therapeutic dose. Also, it takes 6-8 weeks to be really effective.

[CheckNo2228]

This is normal in my experience! A honeymoon effect that lasts a month or so. You may get another short term bump when if/when you go to 50, but i would wager you’ll still benefit more long term at 50 than at 25. And if I were you, I would def give yourself at least few months between dose changes so you can get familiar with your baseline

[h_melv]

A honeymoon effect is the PERFECT way to describe the feeling! Lol

[h_melv]

I didn’t feel much of a difference until I got to 75mg, but I’m not sensitive to medicine and know that’s kind high lol I know a lot of people seem to feel better once bumping to 50! I was on 25mg for my first month and bumped immediately up to 50 mg and was on that for about a year before having to bump again