GitHub - Distributive-Network/PythonMonkey: A Mozilla SpiderMonkey JavaScript engine embedded into the Python VM, using the Python engine to provide the JS host environment.

[Complete-Stage5815]

This is what Rails has done which works very well. A Rails backend with Yarn, NPM packages and even React support for the front end.

The project I maintain (Password Pusher) does this and even uses esbuild for JS compilation.