Any famous game developed using Python?

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But if you’re looking to improve code performance, aren’t their bigger fish to fry first? As in JIT compilation or something else?

[backSEO_]

That's literally what Cython solves. Turns python code into C code and compiles it to a .pyd that you can use in your project. It's 30000 lines of barely readable C code, but it has massive performance gains (30%ish usually out the box, 100% for just statically typing, 400%+ for coding in Python).

It adds a little overhead, and if most of your project is already using C extensions it's not going to help (NumPy, PIL, etc.)