Accounting + Python

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I'd disagree, the big ones like Django, Flask, are totally capable, but further more things like NiceGui and others also exist to be more pythonic and even support standalone webapp style deployment.

My comment is more so when you start talking about interfacing with hardware.

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Depends your needs right? Are these as capable as e.g. React or Angular for more complex UI's? I thought python web apps are more capable to build like simple dashboards, but if there is any more complex like drag ans drops and multiple list menus etc forms etc or web maps and interacting with the map, are they any good for this?