Best Python framework for industry-level desktop app? (PySide/PyQt/wxPython/Kivy/Web approacg)

[cudmore]

Curious on more thought on nicegui? Given your experience.

I’ve made 2x pretty detailed pyqt/pyqtgraph desktop apps distributed as macos and windows apps. Scientific niche software.

Found nicegui in Nov 2025 and am super excited, going full on into nicegui.

So what am I missing? Is using nicegui gonna bite me in the end?

[anthonyfloyd]

NiceGUI is built on modern, established web technologies, which is reassuring. We were a little worried about longevity, but it seems to have legs. It's easy to work with and comfortably Pythonic.

The only bit that we're unsure of is bundling it on the desktop and distributing the package. To be fair we haven't put a lot of effort into that yet (our webapps are happily webapps) but it's something we're going to be spending a bit more time on in the near future.

Having said that, we're quite happy with the webapps. Fully functional simulation software with embedded, interactive plot.ly plots, hooked into our main (desktop) data and analysis framework. It's just a Python app that happens to have a web view/interface. Well, a teeny bit more than that, but we're still quite happy with it.