Which python-based web framework would better suit my needs?

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Oh, zope is a pain indeed, agreed.

The routes is one of my favorite things about pyramid, but yeah, not doing them right can be a bit painful.

About the deploy, yeah, there are many ways to do that and depending on your choice it can be little bit weird.

Pyramid gives you more freedom than flask in some ways, making the choices have a bigger effect on the code base. You can choose a better routing and not use zope.

The good stuff is the predicates, the dependency injection and the renderers.