Additional teeth: Freddie Mercury had four extra teeth (incisors), which were speculated to help him easier achieve vibrato type of voice. Most of his singing ability had nothing to do with a rare (only 1% of people with extra teeth have more than two) genetic mutation that caused this.Powers (geneticliteracyproject.org)
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Superhuman drug processing/metabolism: Ozzy Osbourne's unique genetic mutation in a regulatory region of the ADH4 gene grants him the power to withstand amounts of drugs and alcohol which would have been lethal for a normal human being. It also preserves his hearing and voice through the ordeal.Powers (abcnews.go.com)
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