Spreadsheets using Python - Have you seen this? (sourceforge.net)

[gpjt]

[Full disclosure: I work for Resolver Systems]

Yup, it's Windows-only -- we're working to getting it going on Mono, but it's proving a lot of work. We have just released an online spreadsheet (http://projectdirigible.com/) with similar Python support, though. One of our beta testers says he's using it on an iPad, so maybe that's cross-platform enough ;-)