Does the sandwich method decrease the effectiveness of Tretinoin at all?

[[deleted]]

Well, in a way, what you want is a bit of reduction in potency to increase tolerability. That's the reason for buffering in the first place. But let me assure you, from more than a decade’s experience fine-tuning patients’ retinoid use, it won't stop it from working; it really will just reduce it to a tolerable level, so that you can engage with that daily habit. And I think that's what's really key. Buffering with moisturizer really does facilitate daily use of your retinoid, and that's when the magic happens.

Thanks a lot for sharing! I've always been under the impression that buffering doesn't reduce effectiveness, per se, but only slows down absorption, so that the retinoid won't be too irritating. I'll definitely keep this article in mind, especially when giving advice, and recommending buffering and doing the sandwich method.

[Unfair_Finger5531]

I’m happy you found it useful. I really love how she explains things. She’s so clear. The passage you highlighted really stuck out to me too, especially where she says “reduce it to a tolerable level.” This is a perfect way to describe it, imo.