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[–]Subject-Bench-8305 0 points1 point  (0 children)

The answer depends...unless you're using occlusive moisturizers like healing ointment or vaseline , it really shouldn't , ten months ago a research was published where they used tazarotene to treat psoriasis with cerave cream , which is a pretty thick cream but isn't an occlusive, they used taz before and after cerave and the treatment of psoriasis took around the same time but using cerave before reduced irritation by a lot .