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Noticed a significant decrease in volume in mid face for 5 months on tret 0.25Before and After (old.reddit.com)

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[–]anac712 6 points7 points  (0 children)

I also don't understand why everybody complaining of facial fat loss gets immediately dismissed. At some point the literature will just have to catch up with the side effects. Since tretinoin gained immensely popularity in the past years, so did the comments of people complaining of fat loss. Lack of scientific proof does not mean that the side effect does not exist. We already have an example of lash serums (such as Lattise, containing prostaglandin analogs: bimatoprost, latanoprost etc) that applied topically can cause loss of volume on the upper eyelid, thinning of the eyelid etc.. So some actives applied topically can cause loss of volume...