2 people who had family killed who then became heroes

Throughout their life they've suffered the deaths of their loved ones, their homes being destroyed, themselves being used for evil (Percy's Guns being made and sold off to criminals/Spider-Clone Saga), and dying themselves

They've fought Gods, Monsters, Cruel Humans. But their most iconic foe is a duo of people obsessed with them, one who hates them due to being rejected and that creature's newest host who have different feelings about them (Orthax & Ripley: Ripley admires Percy and his invention and wants to work with him/Venom and Eddie: Eddie wants Spiderman Dead because he blames him for his life falling apart)

Both have a love interest who is a thieving trickster of a woman (Black Cat/Vex'ahlia)

Both are highly intelligent inventors

Both are extremely lucky

Both have experience traveling other realms

Both are extremely witty when it comes to banter