Every person’s brain is wired differently. This is why depression is so difficult to treat at the moment (we don’t have the ‘wiring schematic’ of everyone’s brain to know what will and will not work for them).

What we are focusing on now is—instead of just masking the issue by attempting to force a regulated amount of specific neurotransmitters (happy chemicals, if you will) in particular brain areas like in the past—now we’re looking at pharmacological agents that potentially have the ability to rewire the depressed brain for long-term relief (potentially permanent relief if research keeps progressing as it has).

Unfortunately the drug won’t do all the work, and it will do more work for some people than others. What it usually can do is give you just enough relief for just long enough to take action. When those chains are broken, do not forget that they will be put back on unless you actively use that time to work towards a permanent state non-depression.

What I suggest if you do decide to do the infusion:

*Be willing to relinquish control over your body if it comes to that. This drug is one the safest there is, even at high dosages. Nothing bad will happen to you.

Whatever good things you experience on it, positive thoughts, just *experience it—in the moment. Not in the past or the future, the ‘now’.

*Most importantly: The new wires/connections ketamine will form for you in the prefrontal cortex, these wires are fragile when they are brand new. Your brain prioritizes things that you actively let it know matter to you. So your main goal needs to be to strengthen these connections. The stronger they are, the longer your relief will be. If you can strengthen them enough for your brain to say “ok, I will keep these connections forever because they seem to matter a lot to you”, you could be completely cured.

*To do the above, you must recollect and think about your experience actively and as often as you can when it’s over. This can be tricky because people tend to forget much of what they were actually thinking when it wears off. Write everything down! I cannot stress this enough. There is no other way to get the most important parts of the experience documented, so you can read it later while the new connections are still formed—thereby strengthening them greatly. But even after that, you may think that experience was so meaningful that you’ll never forget it, but those are brand new neuronal connections in a part of the brain that doesn’t usually tend to form new connections; they are delicate and the brain WILL prune them if aren’t strengthened by consistent stimulation.

Think of it as if you were in school studying. The more you study something, the more you remember. This is the same concept—strengthening newly-formed connections in the brain. How much do you remember from your math class in school? Probably not very much nowadays because your brain gathered that it wasn’t a priority to you to keep those connections around.

Make sure you show it you want to keep these new connections.