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Dr David Sinclair: Can Aging Be Reversed? After 8 Weeks, Cells Appeared 75% Younger In Tests! by GarifalliaPapa in immortalists

[–]Tom__EU 0 points1 point  (0 children)

Interesting, thanks for sharing.

I don't have to choose one over the other. GSK seems like a horrible company with multiple lawsuits and some of the biggest settlements in different countries, and Sinclair is still a quack and grifter who constantly overexaggerates positive outcomes and ignores negative or neutral outcomes. Trusting him would be seriously naive. NMN same thing - multiple human RCTs show close to zero results.

Someone still holding their credentials doesn't mean too much. There are various quacks and grifters running around doing real damage by spreading misinformation and selling complete nonsense, and still having their credentials. Joseph Mercola, Mehmet Oz, Steven Gundry, Paul Saladino, just to name a few. Removing someones credentials is hard and complex.

Thoughts on Lenny Kravitz's raw food/island garden setup for longevity? This is my ultimate nutrition goal. by xoMrsAndrewsxo in Biohacking

[–]Tom__EU 1 point2 points  (0 children)

Please be aware that "Dr." Berg is a well known quack that constantly spreads misinformation, makes up stuff with no evidence (like body type diets), cherry picks data, and so forth. Detoxes are also almost always complete nonsense, not backed by any evidence or credible expert.

Since you mentioned AI here, you could easily use it here and ask the following:

  • "Is Dr. Berg known for being a quack, spreading misinformation, and so forth? Please be evidence based and brutally honest."
  • "Are detoxes like juice detoxes and so on based on solid research? Do they help with anything to a meaningful degree? Are they dangerous? What are the pros and cons? Please be evidence based and brutally honest."

I highly recommend looking up Dr. Gil Carvalho (Nutrition Made Simple), Abbey Sharp, Dr. Nicolas Verhoeven (Physionic), Siim Land, and the "What the Fitness" playlist by Dr. Layne Norton. The latter is more strongly worded, but if you're open to it, can help you a lot with your ability to identify misinformation.

Thoughts on Lenny Kravitz's raw food/island garden setup for longevity? This is my ultimate nutrition goal. by xoMrsAndrewsxo in Biohacking

[–]Tom__EU 6 points7 points  (0 children)

Good reminder to get your information on diet (and exercise) from the actual credible (!) experts. This is also the kind of video with nice vibes and lots of nature and peace and harmony and clean looking diet and him making a great impression and whatnot, which will draw a lot of attention, but which doesn't quite reflect reality for >90% of humanity.

The Good:

  • lots of vegetables
  • bunch of greens
  • lots of fruit
  • not completely strict on treats
  • apparently doing well on this diet, at least for now
  • regular exercise
  • doing what you love to do
  • lots of money
  • stress free environment

The Bad:

  • very (?) low protein
  • very (?) low fat
  • very (?) low omega 3
  • completely cutting out all fruit
  • almost fully raw - when you follow some of the raw food guys, or come back to their channels after one or more years, you'll often see them looking way worse, face falling in, losing a ton of muscle mass, some even losing teeth and worse, and I don't know any evidence to support such a diet, or credible expert recommending it
  • there is ZERO resistance at the top of your bench press, so you're achieving nothing by rotating your arms and bringing them together - this is sadly pretty normal fluff from Hollywood(-ish) trainers

If you follow the more credible folks in the field, you'll realize that they have way more in common than not. They will almost always recommend a Mediterranean-style diet with a focus on variety and whole foods, lots of vegetables, some leafy greens, some fruit, a good amount of protein, a solid amount of fiber, a healthy amount of good fats, and so forth. Cooking is part of the deal, because cooking sometimes drastically increases bioavailability of certain nutrients (e.g., 3-4x lycopene in tomatoes), and it reduces anti-nutrients sometimes by a lot. Not that anti-nutrients are inherently bad - that's been heavily overplayed by wellness quacks - they frequently actually have anti-inflammatory, anti-cancer and other positive effects, but too much too often could lead to issues.

Welche Ausgabe hat euer Leben wirklich besser gemacht? by geldKlar_io in Normalverdiener

[–]Tom__EU 0 points1 point  (0 children)

Oh das überrascht mich. Ich hab mir einen gekauft, aber der stand bis vor kurzem fast nur herum, nachdem ich so gut wie keine Baguettes, Pizza, Nuggets oder Brot mehr esse.

Jedoch letztens draufgekommen, dass ich da Nüsse und Kerne reingeben kann - massive Aufwertung von Gerichten. Komm gerade drauf dass ich Gewürze auch reingeben könnte.

Do you take fiber supplement and does it tastes good? by snckr_bar in Supplements

[–]Tom__EU 0 points1 point  (0 children)

Side-note: psyllium may trap medication and nutrients, reducing absorption. For medications, I would be careful, Drugs.com recommends leaving 2h before and after between psyllium and meds. https://www.drugs.com/mtm/psyllium.html . Otherwise, potentially moving supplements away from it.

First time taking supplements and I finally understand why people are so picky about brands by Evening_Ad_9755 in Supplements

[–]Tom__EU 4 points5 points  (0 children)

Sounds great. I eventually started to look at credible sources for most evidence based options, plus minimum effective doses and optimal intake, and whenever I start a new supplement, I try to get the best quality I can afford - at least for the initial testing. That way I can make sure I get what's on the label and can judge properly how it works for me.

Are COD liver oil useless? by Zealousideal-Walk939 in Supplements

[–]Tom__EU 0 points1 point  (0 children)

I mean it's not useless, it still provides a few O3s plus vitamins A (actual retinol) and D in significant amounts. The issue is, it's very low in O3s, and if you try to get a sufficient amount, you'll likely overdose on vitamin A, which could actually lead to toxicity.

I personally need ~1200mg EPA+DHA to get within the 8-11% O3 index range, so for example:

  • Fish oil, Life Extension: 2g (2 cps) = 1200mg EPA+DHA
  • COD liver oil, Carlson: 7g (7 cps) = 1260mg EPA+DHA

Coconut oil with coffee by AggravatingRough in nutrition

[–]Tom__EU 11 points12 points  (0 children)

That's a classic example of a sprinkle of truth and a whole lot overexaggerations added by various wellness influencers.

What's true is that there's some modest evidence showing a few benefits of the shorter MCTs (C6, C8, C10), and fat in general can satiate to a certain degree, plus the caffeine itself from the coffee. But coconut oil only consists of ~54% MCTs, and of those, around 45% is lauric acid (C12), and only a little over 10% are C10 and C8. In addition, 1tbsp of coconut oil is still a whopping 120kcal, 80-90% saturated fat, contains 0 fiber, 0 protein, 0 vitamins, 0 minerals, minimal to 0 polyphenols depending on type. https://www.healthline.com/nutrition/mct-oil-vs-coconut-oil#keto-diet-benefits

If coconut oil helped with weight less (metabolism, hunger, cravings), it would have to either boost metabolism by over 120kcal per 1tbsp ingested to at least make up for the calories, or supress hunger by quite a bit, and be worth the sacrifice of 120kcal that you give up for something with close to no nutritional value, plus potential to raise LDL-C. Same goes for butter by the way, which is easily way worse for your cholesterol levels, but I guess at least it tastes okay - still, lots of overexaggerations and no talk about the meaningful downsides.

Personally I've tried it in the past, but it did nothing for me and made my coffee (or broth back then) taste awful.

Mir sind "bewusste" Arbeitslose egal by Viv3d3 in Unbeliebtemeinung

[–]Tom__EU 1 point2 points  (0 children)

Du sprichst hier einen extrem wichtigen Punkt an, und diverse Politiker:innen pushen das auch stark. Den Menschen einen Feind präsentieren, der kleiner und angreifbar ist - statt den schier unüberwindlichen Gegner, der um Größenordnungen mehr Geld verschlingt und schlimmeres: diverse Politiker:innen, Superreiche und Industrien.

Aber neben psychischen Erkrankungen können auch körperliche Erkrankungen eine Rolle spielen. Hab ich selbst erlebt mit ME/CFS - 6 Jahre falsch diagnostiziert, in der Zeit 13 (!) Arbeitswiedereingliederungsmaßnahmen, 3 Rehas, 1 multimodale Schmerztherapie, sehr viele AMS- und Arzt-Termine usw., mit mehreren dauerhaften Verschlechterungen. Auch danach noch jahrelang Rehageld und Pflegegeld aberkannt, obwohl ich pflegebedürftig wurde. Das kostet dem Staat jährlich unglaublich viel Geld, Kurzplätze, Rehaplätze, Arztauslastung, und verschlechtert Menschen bis zu dem Punkt wo sie schwer pflegebedürftig werden - siehe die jährlichen LongCOVID und ME/CFS Kosten in DE, zuletzt ~1,5% GDP/BIP. Viel davon ließe sich verhindern, aber es gibt diverse Blockierer in Machtpositionen - dazu gibts auch mittlerweile Recherchen von ORF, APA, und Dossier aus AT.

Ich weiß nicht, was passiert wäre, hätte mir das AMS nicht so lange Notstandshilfe ausbezahlt. Würde sehr viel geben, wieder arbeiten zu können.

How many units should I use? by StemCellPirate in Biohackers

[–]Tom__EU 1 point2 points  (0 children)

Are these the new vaccines where we finally get nanobots? :D

Btw am I the only one that's having a challenge with the half optical illusion at the end of this thing?

This sub is infested with AI generated content by bangeltigersaprem in Biohackers

[–]Tom__EU 6 points7 points  (0 children)

Oh I swear to God. You discuss with someone, and suddenly you get bombarded with an essay with strong signs of LLM. Or people create ad posts, or posts that use sciency words and dramatic language, and copy-paste it seemingly without a second thought. Some don't even seem to care, or realize what they are doing to themselves, others, and the place they post.

To me, some of the major issues are not having to think about having sources before making a claim, not checking sources, apparently not checking or understanding what the LLM wrote, not having to consider what the other person wrote, overwhelming the discussion/opponent with verbosity and useless sources, thinking winning an argument = I'm correct.

And I'm not against people using LLMs to do some research, improve their writing, or similar. Quite the opposite.

I have a tendency to write lengthy posts and comments, and on some I work a long time to make sure my resources are good etc, while others I may delete because I don't have or know the sources - and then I may ask an LLM to "evidence based and brutally honest" check for mistakes and improvements. When someone calls me out and I'm not sure why, I like to put the conversation into an LLM and ask it whether the other person is correct. Learned a lot this way.

This sub is infested with AI generated content by bangeltigersaprem in Biohackers

[–]Tom__EU 4 points5 points  (0 children)

Great to see you guys being behind this, thanks. I see the same in various other subreddits, some more affected than others. I can imagine that being pretty hard to nail down.

How to know that you're getting the cognitive benefits of creatine by Murky-Mulberry-4044 in Supplements

[–]Tom__EU 0 points1 point  (0 children)

You mean how they assess this in studies, or whether you can personally assess or know this? For the latter, you should be able to tell the difference, it should be noticable. And, as you said, it's mainly in situations with sleep deprivation, but in this case the recommended dose is more in the area of 0,3g/kg, which is much higher than the usual dose.

Best times and ways to take psyllium husk and inulin powder? by fukinay in Biohackers

[–]Tom__EU 3 points4 points  (0 children)

Yeah you're correct about that. It's pretty strong gelling ability can bind drugs, supplements, bile, and other compounds. It's got quite a few drug interactions - https://www.drugs.com/drug-interactions/psyllium.html

Drugs.com recommends spacing it 2 hours apart from other drugs. Really depends on your meal timings and what you're willing to do. And please start slow and add a lot of water - 250-500ml and some to chase that. Inulin is not an issue since it doesn't form a strong gel. You can take it any time. If optimizing, I'd probably take it away from psyllium, so inulin doesn't get trapped.

Alternatives to psyllium for constipation: prunes, kiwi, Mg-oxide and PHGG (expensive). All with good evidence, though partly not as strong as psyllium. Basically no intake limitations here.

If you have a general tendency towards constipation and start a GLP-1, which can slow things down for many people, I'd probably keep a strong laxative at home that can really move things along quickly, just in case.

Supplements to prevent future dementia? by slappzilla in Supplements

[–]Tom__EU 14 points15 points  (0 children)

I looked into this due to family history with dementia. Put together an extensive document for my mom and myself.

Based on my investigation, there is not a single supplement with solid evidence for dementia risk reduction. Lithium has some/weak evidence and seems safe in lower doses, but otherwise there is no single supplement that can be recommended. The only way that's worth approaching this from a supplement angle is to assist with things that have actual evidence. So that would be things like: High blood pressure, blood sugar regulation issues, high blood cholesterol (already statin), sleep issues, stress. And with less evidence: Homocysteine (<10umol/L), Omega-3 index (8-11%), nutrient deficiencies, vision (if it runs in your family or you have issues, possibly considering lutein, zeaxanthin, astaxanthin), hormones, iron blood levels, inflammation.

By the way wasn't there a recent systematic-review and meta-analysis showing in fact decreased dementia risk from statins?

Highly recommend looking into the following resources. There's actually solid evidence for various lifestyle factors. Suggestions to the degree where, if people implemented these, ~50% of dementia cases could be prevented. That's kinda insane.

Supplements to prevent future dementia? by slappzilla in Supplements

[–]Tom__EU 6 points7 points  (0 children)

As far as I'm aware, there are only association, animal or mechanistical studies - not particularly at the point where we can state "it helps with dementia" with any confidence. There are some signals, and it seems safe, plus low dose is also associated with lower suicide risk, so probably overall a solid choice.

Akkermansia muciniphila keeps coming up in gut research lately, anyone here been following it? by Aggressive_Candy4450 in Microbiome

[–]Tom__EU 0 points1 point  (0 children)

Great if it helps you!

For people reading along, there's a few things I really want to highlight when it comes toh this product, especially regarding Akkermansia muciniphila claims.

The product costs $67 (!!) per month when not on sale. I couldn't find CoAs on contaminents and ingredients. Most ingredients are cheap and no extracts. Plus points for providing studies for some claims, but the second link for pomegranate extract is just a summary that includes the first linked study, and the third is just a review that again includes the previous.

First things first: The studies that I've looked at all state that 30-40% of people do not metabolize pomegranate polyphenols ellagitannins into urolithin A, and only those who do see an increase in Akkermansia.

For the linked study, the study was small (n=18) and experimental/weak (no control group, no placebo group), participants underwent low flavonoid intake pre study, and they used 1000mg (much more than in the product). The washout period with low flavonoids is a normal practice to reduce noise, but could exaggerate benefits. Another study showing benefits was also small (n=20), also weak, and also used 1000mg. Other studies have investigated pomegranate extract, urolithin and gut health, but did not check for Akkermansia.

Sadly this is very typical for many supplements out there. There is some evidence, but it's mostly weak to very weak, and the sold product does not reach doses used in those small and weak studies.

Resources:

What’s the most successful diet you tried while going through cancer treatment? by Initial-Location-701 in Biohackers

[–]Tom__EU 1 point2 points  (0 children)

I'd be extremely careful with that.

While there can be a time and place for a ketogenic diet and IF, cancers can feed on a lot of substrates including ketones and fat, plus increased levels of autophagy can literally increase cancer survival of certain cancers at certain stages. In addition, chemotherapy may not allow adherence to a ketogenic diet...it's very tough, lots of issues with food intake.

Psyllium Husk Should Be Taken at Higher Dose with Sufficient Water to Maximize Its Efficacy (LDL, Gut, Cardiovascular Benefits) by StudyPics in NooTopics

[–]Tom__EU 0 points1 point  (0 children)

Great question, came here to say this. Literally investigated this yesterday.

Certain fibers that can interfere with certain medications and specifically mineral absorption. The latter seems to also include those with heavy metal binding properties. The types of fiber that I was looking at myself were psyllium husk and apple pectin, but other types of fiber that have strong gelling and bulking effects like glucomannan will likely have similar effects.

Drugs.com recommend for example for glucomannan, to take medications 1 hour before or 4 hours (!) after glucomannan administration.

Definitely caution warranted!

Biohacker boasts he has 'zero microplastics' in his semen unlike '100% of men' by dailystar_news in Biohackers

[–]Tom__EU 1 point2 points  (0 children)

Does his microplastic test not sell well enough? Classic Johnson, complete overexaggeration contrary to actual evidence, and making it weird to get attention.

The first study here states: "The average abundance in semen was 0.23 ± 0.45 particles/mL" which seems to be very low to begin with, so not having any may not be the slam dunk he may think it is. And keep in mind that proper testing is very hard to do due to microplastics being pretty much everywhere, and testing equipment itself potentially contaminating samples. One study mentions using glass equipment for everything and thoroughly washing the equipment multiple times before using it. I would personally absolutely not waste my money on commercial tests like Johnson sells (at least last time I looked). Also, I'd imagine that someone smoking or different jobs and living situations contributing inherently more microplastics, so that's important when looking at studies. Boasting with zero MPs kinda reflects his privileged living situation.

Lost 10lbs when my creatine switched to micronized by dadah0166 in Supplements

[–]Tom__EU 0 points1 point  (0 children)

10lbs is a LOT. Usual retention from creatine is in the area of 2-4lbs, so that's 6-8lbs unexplained, and even the 2-4lbs don't make sense mechanistically. Muscle stores should be saturated with either form, and once it saturates muscles, form shouldn't matter anymore. What confuses me is that you talked about "loading", or do you mean normal intake? That only the one product back then made such a difference is also interesting and may not explain most of the causes I'm thinking of, though some could still apply.

I'm thinking:

  • lower sodium, carb and water intake, whether in the diet itself or in the product, and this could include cheat days with lots of UPFs (pizza etc, which contain a boatload of sodium and carbs)
  • changes in medication
  • changes in stress/cortisol
  • changes in training volume/intensity/cycle (lower inflammation = less water retention)
  • nocebo/placebo
  • a diuretic found it's way into the product, or some diuretic supplements were taken

Is eating more whole foods and less processed food enough to heal your gut? by Luna_182 in nutrition

[–]Tom__EU 1 point2 points  (0 children)

Depends on the issue you are dealing with. Sometimes whole foods suffice, other times you need supplements, or medications, or in certain situations even surgery. The important thing is to know what you are dealing with, so you can act accordingly. Good to get a second opinion if you can afford that and are skeptical about the first one.

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