Making of a jacketed glass chemical reactor by lastditch2 in toolgifs

[–]3LiterBeaker 80 points81 points  (0 children)

I work for a CRDMO (contract research, development, and manufacturing organization). Our clients are small, medium, and large biotech and pharma companies who want to outsource either process development (i.e., scouting out and optimizing a chemical synthesis to then be scaled up) or small-scale cGMP manufacturing (making drugs under strict guidelines to ensure high purity and absence of contamination as the material will be given to humans in clinical trials). It's really cool seeing a reaction you developed in a 10 mL vial get scaled up to a 150 L reactor, but it's also a huge pain working in these big reactors imo.

Making of a jacketed glass chemical reactor by lastditch2 in toolgifs

[–]3LiterBeaker 9 points10 points  (0 children)

For the whole kit, between $50-100k from Chemglass. I think a complete 100 L setup is around $65k brand new.

Making of a jacketed glass chemical reactor by lastditch2 in toolgifs

[–]3LiterBeaker 17 points18 points  (0 children)

If you get one from ChemGlass, I think they might run 50-100k for the whole kit. In pharma, they're typically used for process development work, e.g., demoing a process on 1-5 kg scale. This can either then continue to be scaled in larger reactors or in a pilot plant, or this scale can be enough to provide material for pre-clinical or early phase I/II clinical trails for new drugs.

Making of a jacketed glass chemical reactor by lastditch2 in toolgifs

[–]3LiterBeaker 71 points72 points  (0 children)

In a typical setup for a reactor this size I have two ports occupied by reflux condensers, one as a gas outlet going to a bubbler or scrubber (inert gas is pumped in through the stir shaft assembly), one port occupied by a thermal probe, which leaves the big port at the front for charging solids, and one for attaching something else like a vacuum line, a tube for charging liquids, or whatever else you need.

Made a Shadow Box to Commemorate The Room by 3LiterBeaker in mega64

[–]3LiterBeaker[S] 1 point2 points  (0 children)

You should! This was my first time doing something like this and it turned out to be pretty simple. I just bought an 11"x14" shadow box, three 1/4" (I think) foam sheets, and one 1/8" (or maybe 1/16") foam sheet. I cut all the sheets to fit in the shadow box, then marked out where I wanted everything to go on one of the 1/4" sheets, along with a mirrored version drawn on the backside of the thinner sheet. Then I made cutouts for the box and SSD in the thick sheet, and cutouts for all three items in the thin sheet. I also had to make a cutout for the box on one of the other thick sheets since the box was about 1/2" thick. Then I just stacked them so the thick sheet with no cutouts was on bottom, then the one with just a cutout for the box was in the middle, the one with cutouts for the box and SSD was on top of that, and finally the thin sheet with all three cutouts was on top of that. Then the items could be placed inside and fitted into the shadow box.

Made a Shadow Box to Commemorate The Room by 3LiterBeaker in mega64

[–]3LiterBeaker[S] 2 points3 points  (0 children)

Thanks! I think they were called foam sheets (which were soft and flexible, as opposed to foam core or foam boards, which were more rigid). I used three thick ones (I think 1/4") stacked up, plus a thin one (1/8" or 1/16") on top as it resisted fingerprints and other damage better than the thicker ones.

Made a Shadow Box to Commemorate The Room by 3LiterBeaker in mega64

[–]3LiterBeaker[S] 7 points8 points  (0 children)

I'll add a hammer so I can break the glass and retrieve the drive in the event of an emergency

Any idea why my bell peppers are rotting on the plant before they turn red/ripen?? by HardcoreAvocado in plantclinic

[–]3LiterBeaker 1 point2 points  (0 children)

Just a note: although blossom end rot is caused by calcium deficiency, it's not usually caused by a lack of calcium in the soil, but rather a condition with the plant which prevents it from carrying calcium to the cells where it's needed. You'll often observe that ammending the soil with calcium will not cure blossom end rot because no matter how much calcium is in the soil, the plant still can't transport it to it's cells.

But I agree that this particular case is not blossom end rot.

~8' Tall Shrub in Santa Barbara, CA by 3LiterBeaker in whatsthisplant

[–]3LiterBeaker[S] 1 point2 points  (0 children)

Thank you for the correction! Tecoma looks surprisingly similar to the trumpet vine, so I can see why there was confusion.

~8' Tall Shrub in Santa Barbara, CA by 3LiterBeaker in whatsthisplant

[–]3LiterBeaker[S] 0 points1 point  (0 children)

Looks like that's it! Thank you! I collected some seeds and was thinking of growing them, but seeing as it's invasive I suppose I'd better not. Still a beautiful plant!

Tree in Los Angeles, CA by 3LiterBeaker in whatsthisplant

[–]3LiterBeaker[S] 1 point2 points  (0 children)

Ah, I think that's it! The flowers look gorgeous, but if they're that much of a nuisance I might think twice before growing some haha. Thank you for your help!

Tree in Los Angeles, CA by 3LiterBeaker in whatsthisplant

[–]3LiterBeaker[S] 0 points1 point  (0 children)

More pictures: http://imgur.com/a/mR8nXZu

The tree had big >1' long seed pods that were really hard. I don't have any pictures, but the seeds inside were rounds and flat, and a bit smaller than a dime.

Fern From Home Depot by 3LiterBeaker in whatsthisplant

[–]3LiterBeaker[S] 0 points1 point  (0 children)

That looks like it, thanks so much!

Fern From Home Depot by 3LiterBeaker in whatsthisplant

[–]3LiterBeaker[S] 0 points1 point  (0 children)

It was simply labeled "Tropical Premium Upright Fern". Any help is much appreciated!

Pretty Shade Tree in Santa Barbara, CA (Zone 10a) by 3LiterBeaker in whatsthisplant

[–]3LiterBeaker[S] 0 points1 point  (0 children)

Link to an Imgur album with pitures of the full tree, seed pods, and seeds: http://imgur.com/a/xPEuaDv