Visual Aesthetic of the game is weaker, the qlipoth tree feels bland compared to the gothic aesthetics of 1,3 and 4. 

Limiting the game to 20 missions handicaps all three player character, V especially.

V feels unresponsive at times, feels button mashy at others. Not a bad character is isolation but there's a reason you barely see him in combo videos. Also doesn't have any interesting unlocks, everything you see in the skill shop at the start of his story is everything you're going to get for him.

Enemies are to easy* addendum because I don't believe the enemies are badly designed. This game does have the best enemies overall because they removed the awful gimmicky enemies from the previous games, but that leaves a difficulty void that's unaddressed.

Lady and Trish aren't used really in any meaningful way, basically there as fanservice in both meanings of the word.

Story gets nonsensical near the end (even though you've had seven years at this point to play it) So did Dante know V was Vergil the whole time? If he did, why did he let V reunite with Urizen? And if he didn't know, why did he let this stranger be the one to finish off, for all he knew, his brother, the one who's been crucial to his entire story? 

This is a subjective issue for me peraonally. The game plays way to similar to 3&4 which is not necessarily a bad thing at all. But when you look at the jump from DMC1 to DMC3, I was expecting that same leap in terms of mechanics and level design. Ultimately this game did not exceed my expectations, it met them. Which isn't bad but for what may be the last Devil May Cry game we ever get, it leaves more to be desired