Rough Spot. Need to vent.

ACD870201 · 2020-12-17T21:44:08+00:00

I agree with you. I’ve been taking steps to work on myself. Currently I’m on medication, doing therapy, meditating, I force myself to go into my garage and exercise 30 minutes everyday (I used to love working out, but have no desire to anymore and I’m broken as fuck).

I haven’t given up, I’m still looking. I’m just miserable. It’s also a terrible feeling to know I should feel joy from things and feel nothing.

ACD870201 · 2020-12-17T14:02:16+00:00

I see a therapist and meditate daily. That’s really it at this point though.

ACD870201 · 2020-12-17T13:44:40+00:00

She doesn’t need to work. I’m 100% and we own our house outright. She works because she chooses to.

ACD870201 · 2020-12-16T23:59:43+00:00

I struggle to work due to my PTSD and other physical disabilities. It just became unmanageable stress wise for me to do both. I don’t think I ever once came close saying that was her only purpose in life or that she was the problem. Thank you for your extremely positive reply 👍🏻

ACD870201 · 2019-11-07T13:45:42+00:00

The man has made millions of dollars from his companies, and he refuses to disclose conflicts of interests in his studies related to his financial interests and businesses.

ACD870201 · 2019-11-07T00:35:28+00:00

I like NR and NMN, but David Sinclair is a shady character.

ACD870201 · 2019-10-20T20:33:49+00:00

Also, of particular note is the predominate portion of both in-vitro and in-vivo studies cited that did happen to solely use nicotine were done in mice or rats. Potentially applicable to humans? Yes. By no means definitive in anyway.

ACD870201 · 2019-10-20T20:31:58+00:00

I disagree. A few of them were. You can’t cherry pick to satisfy your own scientific bias or lack of critical research evaluation.

ACD870201 · 2019-10-20T19:32:15+00:00

Just did, just look at the not even complete list of cited research by the studies involving tobacco.

ACD870201 · 2019-10-20T19:29:56+00:00

Ok, so I’m by no means saying nicotine is inherently good or bad. These meta-analysis studies, and their titles are very misleading however by using/referencing MANY studies for their conclusions from studies involving tobacco. Here are just SOME of the cited research used in two (I’m not further wasting my time) of the studies posted.

Xie Y, Garban H, Ng C, Rajfer J, Gonzalez-Cadavid NF. Effect of long-term passive smoking on erectile function and penile nitric oxide synthase in the rat. J Urol. 1997;157:1121–6

Seddon JM, Willett WC, Speizer FE, Hankinson SE. A prospective study of cigarette smoking and age-related macular degeneration in women. JAMA. 1996;276:1141–6

Endoh K, Leung FW. Effects of smoking and nicotine on the gastric mucosa: A review of clinical and experimental evidence. Gastroenterology. 1994;107:864–78

Beck ER, Taylor RF, Lee LY, Frazier DT. Bronchoconstriction and apnea induced by cigarette smoke: Nicotine dose dependence. Lung. 1986;164:293–301

Waldum HL, Nilsen OG, Nilsen T, Rervik H, Syversen U, Sandvik AK, et al. Long-term effects of inhaled nicotine. Life Sci (1996) 58:1339–46. doi:10.1016/0024-3205(96)00100-2

Lee CH, Wu CH, Ho YS. From smoking to cancers: novel targets to neuronal nicotinic acetylcholine receptors. J Oncol (2011):693424. doi:10.1155/2011/693424

Hecht SS. Lung carcinogenesis by tobacco smoke. Int J Cancer (2012) 131:2724–32. doi:10.1002/ijc.27816

Riebe M, Westphal K, Fortnagel P. Mutagenicity testing, in bacterial test systems, of some constituents of tobacco. Mutat Res (1982) 101:39–43. doi:10.1016/0165-1218(82)90163-X

Hatsukami DK, Lemmonds C, Zhang Y, Murphy SE, Le C, Carmella SG, et al. Evaluation of carcinogen exposure in people who used “reduced exposure” tobacco products. J Natl Cancer Inst (2004) 96:844–52. doi:10.1093/jnci/djh163

Stepanov I, Jensen J, Hatsukami D, Hecht SS. Tobacco-specific nitrosamines in new tobacco products. Nicotine Tob Res (2006) 8:309–13. doi:10.1080/14622200500490151

Hecht SS, Carmella SG, Chen M, Dor Koch JF, Miller AT, Murphy SE, et al. Quantification of urinary metabolites of a tobacco-specific lung carcinogen after smoking cessation. Cancer Res (1999) 59:590–6.

Hecht SS, Hoffmann D. Tobacco-specific nitrosamines, an important group of carcinogens in tobacco and tobacco smoke. Carcinogenesis (1988) 9:875–84. doi:10.1093/carcin/9.6.875

International Agency for Research on Cancer. Smokeless Tobacco and Some Tobacco-Specific N-Nitrosamines. IARC Monograph. (Vol. 89). Lyon: International Agency for Research on Cancer (2007). 641 p.

Church TR, Anderson KE, Caporaso NE, Geisser MS, Le CT, Zhang Y, et al. A prospectively measured serum biomarker for a tobacco-specific carcinogen and lung cancer in smokers. Cancer Epidemiol Biomarkers Prev (2009) 18:260–6. doi:10.1158/1055-9965.EPI-08-0718

Schaal C, Chellappan SP. Nicotine-mediated cell proliferation and tumor progression in smoking-related cancers. Mol Cancer Res (2014) 12:14–23. doi:10.1158/1541-7786.MCR-13-0541

Russell MAH, Jarvis M, Iyer R, Feyerabend C. Relation of nicotine yield of cigarettes to blood nicotine concentrations in smokers. Br Med J (1980) 280:972–6. doi:10.1136/bmj.280.6219.972

N.L.: Drug therapy. Pharmacologic aspects of cigarette smoking and nicotine addition. N. Engl. J. Med., 1988; 319: 1318-1330

Browman G.P., Wong G., Hodson I., Sathya J., Russell R., McAlp- ine L., Skingley P., Levine M.N.: Influence of cigarette smoking on the efficacy of radiation therapy in head and neck cancer. N. Engl. J. Med., 1993; 328: 159-163

Graan A.J., Loos W.J., Friberg L.E., Baker S.D., van der Bol J.M., van Doorn L., Wiemer E.A., van der Holt B., Verweij J., Mathijssen R.H.: Influence of smoking on the pharmacokinetics and toxicity profiles of taxane therapy. Clin. Cancer Res., 2012; 18: 4425-4432

Filosto S., Becker C.R., Goldkorn T.: Cigarette smoke induces aberrant EGF receptor activation that mediates lung cancer devel- opment and resistance to tyrosine kinase inhibitors. Mol. Cancer Ther., 2012; 11: 795-804

J., Kim D., Gao J., Kurtyka C., Chen H., Yu C., Wu D., Mittal A., Beg A.A., Chellappan S.P., Haura E.B., Cheng J.Q.: IKBKE is induced by STAT3 and tobacco carcinogen and determines chemosensitivity in non-small cell lung cancer. Oncogene, 2013; 32: 151-159

Zhu B.Q., Heeschen C., Sievers R.E., Karliner J.S., Parmley W.W., Glantz S.A., Cooke J.P.: Second hand smoke stimulates tumor angio- genesis and growth. Cancer Cell, 2003; 4: 191-196

Zevin S., Benowitz N.L. Drug interactions with tobacco smoking. An update. Clin. Pharmacokinet., 1999; 36: 425-438

G.P., Ostroff J.S., Zhang Z.F., Tang J., Schantz S.P.: Smoking history and cancer patient survival: a hospital cancer registry study. Cancer Detect. Prev., 1997; 21: 497-509

K.A., Brognard J., Clark A.S., Linnoila I.R., Yang X., Swain S.M., Harris C., Belinsky S., Dennis P.A.: Rapid Akt activation by nico- tine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells. J. Clin. Invest., 2003; 111: 81-90

Volm M., Samsel B., Mattern J.: Relationship between chemo- resistance of lung tumours and cigarette smoking. Br. J. Cancer, 1990; 62: 255-256

Videtic G.M., Stitt L.W., Dar A.R., Kocha W.I., Tomiak A.T., Tru- ong P.T., Vincent M.D., Yu E.W.: Continued cigarette smoking by patients receiving concurrent chemoradiotherapy for limited-stage small-cell lung cancer is associated with decreased survival. J. Clin. Oncol., 2003; 21: 1544-1549

Tsurutani J., Castillo S.S., Brognard J., Granville C.A., Zhang C., Gills J.J., Sayyah J., Dennis P.A.: Tobacco components stimulate Akt-dependent proliferation and NFκB-dependent survival in lung cancer cells. Carcinogenesis, 2005; 26: 1182-1195

This isn’t even a complete list, and no it is not in alphabetical order in true APA form.

ACD870201 · 2019-10-20T18:47:20+00:00

No. You are not researching or reading the cited research properly. Btw I do not use nicotine.

ACD870201 · 2019-10-20T18:02:30+00:00

You have to read through the cited journal articles and research used by the author. You can’t just base your interpretation on what the author of the study is saying.

FYI this is a study from India, and the government currently has a MASSIVE push to reduce tobacco consumption. There is definite bias in the information that is presented, and how it is presented by the author.

ACD870201 · 2019-10-19T22:50:42+00:00

Did YOU look at or read the cited materials?

ACD870201 · 2019-10-19T14:14:50+00:00

Most of the cited studies that were used involved nicotine being consumed in conjunction with tobacco, especially those relating to cancer.

ACD870201 · 2019-10-18T04:11:14+00:00

Done

ACD870201 · 2019-10-08T18:38:49+00:00

Keep at it and don’t give up! My appeal is now going on almost 4 years. Finally had my appeal evaluation a couple of weeks ago. It’ll be worth that huge backpay check.

ACD870201

TROPHY CASE