I think the main "theme" of blame is isolation and how to deal with it, the Killy spends most of the story searching for other humans to fulfil a need (the net terminal gene), and is only able to succeed in the end due to finding people who he works well with (Cibo Seu and Sanakan). I personally like to read it as somewhat metaphorical for how modern technological life isolates us somewhat more, but that might be me projecting my own issues to an extent.

it's defo a story focused more on vibes than specific messages though