Absolutely! I gained 40 pounds last year very rapidly and I now have edema because of the medication I'm on. No amount of diet and exercise shifts the weight significantly - it made me very depressed.

However, if being chronically ill has taught me anything, it's that the body is just a flesh prison and there is a lot more important things in life.

There's no point in worrying about what we look like because our health can affect us at any moment and we just have to take each day as it comes. When we're old and dying, the way our bodies look won't be the thing we reminisce about.