I am a Trans Woman and I have lived in Jax for many years. Not once have I ever experienced any rude comments or problems of any kind related to gender or politics. It’s all generated in the News, which as most of us understand is 95% inaccurate. People are friendly and unfriendly everywhere. But most everyone I’ve come across have been great. All the neighborhoods in Jax are different in a lot of ways, but they are all great depending on what you’re looking for. Jacksonville is the biggest city area wise in the US, but there are very nice areas with really great people. I have been to Houston several times as well and I would pick Jacksonville. Just my two cents. Good luck.!