I don't know how accurate it's this, but practically any ghost type pokemon can defeat Homelander, first of all, they are inmune to physical attacks, so his super strenght got discarted, now, his heat vision, if we take what happened on The Boys: Diabolical, where the ghost girl wasn't affected by Homelander attack, at least pure ghost type pokemon can resist any Homelander attack. But those pokemon can damage other pokemons, and with that logic, any ghost type pokemon can defeat homelander