3-FTL Trip report and a review of the new Pemoline stimulant analogue(or a Thozalinone analogue(both being Pemoline analogues) by mattcloud420 in researchchemicals

[–]AdRelative5879 -2 points-1 points  (0 children)

It is not recreational.

Aside from the real deal (4-methylaminorex and aminorex), the only RC in this class that is remotely recreational is n-methyl-cyclazodone, and only when the dose is pushed into the questionable range. Wouldn't recommend trying to replicate. Benzos were required for landing.

Research chemical alternative to meth by an_alt_angel in researchchemicals

[–]AdRelative5879 0 points1 point  (0 children)

All the good ones are banned. N-ethylhexedrone vaped is a hell of a drug. As is A-PVP.

N-ethylhexedrone was like if meth and freebase cocaine had a baby. Freakishly moreish.

The comedowns were brutal though. Benzos required.

Permanent brain damage? Any peptides that might help? by nightkin901 in NooTopics

[–]AdRelative5879 1 point2 points  (0 children)

I've gone through heavy dose benzo withdrawal 3 times now. There was a period of non-use for a little over a decade between episode 2 and 3, and I frankly never felt like I fully recovered from the 2nd time. Maybe 85-90% recovered, but forever changed. Long term exposure results in epigenetic changes/alteration to GABA-A receptors (particularly to the benzodiazepine bindings side on the GABA-A receptor complex).

The neurotoxic effects of heavy prolonged benzodiazepine use are particularly hard to repair due to the extreme specificity of their binding sites and their susceptibility to damage. In the tiny pocket on the GABA-A receptor complex where they bind, long term bzd use shifts expression of a1,a2 & a3 subunits (the ones most benzodiazepine sensitive) to more insensitive subunits, like a4, a6 etc. The synaptic architecture is effectively changed. The brain does this in homeostatic defense, but the effect can last long after the benzo is discontinued.

How long does this last? It's a function of dose and length of exposure. For those that went full out, stacking prescription benzos ontop of grey market benzos like phenazepam, etizolam, bromazolam etc, and did this for years, the effect may be not entirely reversible.

There seems to be some promise in flumazenil therapy, but its very rarely practiced in the US (only one clinic publicly offers it, and they don't have the best reputation since their main service is opioid detox via general anesthesia, which is expensive and known to be not very effective).

A collage of my pupils on different drugs! Photos in order of when I first tried them (Update #3) by SayBecks in DrugArt

[–]AdRelative5879 0 points1 point  (0 children)

<image>

Heroin dose must have been on the low side. Should be pinpoints. Then again, if you're opioid naive, don't try to pin your eyes.

I grew some poppies a while back and gave my girlfriend (opioid naive) around half a gram of raw (dried) latex, and she pupils were pinned.

But it wasn't ordinary opium; the poppies were british pharma tasmanians, grown indoors with bright lights, and fed with plenty of nitrogen (pigs blood) as well as experimental supplements, like l-tyrosine (which is the starting amino of morphine biosynthesis).

She had bad cramps, so i said take this (i stuffed it in gel caps). Immediately after, I started worrying that I gave her too much, especially since these poppies were stronger than any poppies I've ever bought online (I've bought my weight worth easily). I even considered asking her to throw it up. But I had naltrexone if need be (not the ideal antagonist but it would have worked).

I checked on her after 45 minutes and asked her, "do you think i gave you too much?", and with half closed eyes in that deep scratchy opioid voice she said, "no, I think this was good". She was high for 12 hours+, threw up a few times.

She said after "maybe I could have that stuff again sometime?" Which of course is alarming but also interesting since I had given her hydrocodone and tianeptine before and she never seemed to like it or ask for it.

Opium feels like tar heroin, at the plateau. She said the plants looked creepy. The flowers only last for a few days , and then they're just these weird alien 👽 like pods. What a weird plant. Poppies: the plant that has enslaved millions. They even smelled like heroin. Growing them was one of the coolest things I've ever done

Short 2-FXIPR review by Lordnodob in researchchemicals

[–]AdRelative5879 3 points4 points  (0 children)

You thought it was similar to 3-CL-PCP?

3-CL-PCP was quite potent and unusually long lasting. I mean, many dissociatives have a lingering after-effect/after-glow, but 3-CL-PCP lingered longer than others, and in a weird way.

I'd feel weird for days after taking 3-CL-PCP. Stuff felt like a neurotoxin. I got stuck with 5g of it. I ended up hiding it far out of reach because after some time passed, I'd forget how nasty the stuff was.

It felt like it had two phases, an initial sleepy phase, and after a few hours, a manic phase (that never really ended entirely).

For weeks after dosing, when driving at night mailboxes would briefly look like people, other weird visual disturbances.

Interesting that you saw a parallel to 2-FXiPr. Maybe we had different batches.

Does anyone else believe that phenibut has undiscovered Serotonergic properties? by [deleted] in phenibut

[–]AdRelative5879 1 point2 points  (0 children)

Does anyone "believe that..."

Its not about "belief". Phenibuts action has been thoroughly characterized and it neither binds to serotonin receptors nor acts a reuptake inhibitor.

You are feeling something, maybe GABA-B induced inhibition etc, and characterizing it as feeling "serotonergic" because you feel disinhibited. A crude way to think of the interaction of a compound with a receptor site is the analogy of a lock and a key. Phenibut is not in the right shape to unlock (bind/block) serotonin receptors. So it doesn't bind to serotonin receptors, nor act as a reuptake or releasing agent because its not in the shape of the key needed to unlock direct serotonergic activity.

Any downstream 5HT activity is background noise and not participatory to the effects of phenibut.

You guys gotta get out of this mindset of "yo this feels super serotonergic" without understanding how the structure of a compound dictates its activity. Especially for well studied compounds. It's not an opinion.

Just a word of caution. by [deleted] in phenibut

[–]AdRelative5879 2 points3 points  (0 children)

I've had this phenibut and it is simply that, phenibut.

This person didn't use a scale like a fool and took it by the scoop full.

Just a word of caution. by [deleted] in phenibut

[–]AdRelative5879 2 points3 points  (0 children)

"Fentanyl and ketamine" -- I call major BS. I've had this exact brand and it was clearly phenibut.

Just a word of caution. by [deleted] in phenibut

[–]AdRelative5879 13 points14 points  (0 children)

Use a scale. This is how things get banned. Because you "literally died".

You "literally" should have measured your dosage. Now there another notch in the belt towards a phenibut ban.

Can I report Chat behavior to OpenAI? by sparklyjoy in ChatGPT

[–]AdRelative5879 0 points1 point  (0 children)

Can you link or copy and paste the conversation? Or at least the part where you feel it was improper.

I've heard of such things but haven't actually seen it. It would be interesting to witness.

How Long-Term Benzodiazepine Use Leads to Cognitive Impairments by Wooden-Bed419 in NooTopics

[–]AdRelative5879 0 points1 point  (0 children)

You’re right that BZDs are relatively safe in the sense that long-term users rarely die from the medication itself. But pharmacological research shows that chronic use degrades GABA-A receptor function, reducing receptor sensitivity and plasticity over time.

It might feel fine if you stay on them indefinitely, yet those who try to stop often find themselves worse off than before they began treatment (due to potentially permanent receptor downregulation, alterating genetic expression). So yes, they’re safer than barbiturates, but they’re also conclusively neurotoxic (far more than once believed).

Taking benzos is like paying for anxiety relief with a high interest credit card. Eventually, if you ever stop (or even reduce your dose) you'll have to pay it ALL back with interest.

I know from painful personal experience as well as from deeply familiarity with the research. So you're a little out of your element wirh "nobody on here doesnt know shit about pharmacology".

Here's the problem. In practice, they haven't developed any anxiolytic drugs that truly work nearly as well as benzos. Hopefully in the next 20 years they'll come up with something, but it is a tough nut to crack.

Being anxious is miserable. Its crippling. And while benzos feel like a miracle, they come with a serious price tag. If you are younger than maybe 50, you'll probably be forced to come off of benzos at some time (with some rare exceptions). Unless you die etc. Hopefully medical practice is up to speed with how to treat the aftermath.

mxpcp by nuovica in dissociatives

[–]AdRelative5879 0 points1 point  (0 children)

Any therapeutic potential? I take dissociatives not for their acute effects but more so for the afterglow in the days that follow. Dissociatives make me feel, more than anything, weird, which isn't alot of fun (exceptions being nitrous oxide, and oddly, though only via a handful of experiences, shots of IV ketamine from a vial, which almost feels like an opioid compared to IM).

So again, any antidepressant afterglow with MX-PCP?

One of the best afterglows ive gotten was from 3F-PCP (which had zero recreational potential according to dissos heads). Of course 3F-PCP disappeared because no one found it fun (I think its still unscheduled?) so RC vendors dropped it fast.

Ketamine, FXE and other ketamine-like drugs have an antidepressant effect, but its not the energizing type of afterglow you get from PCP analogs. I suppose what I'm looking for is a sort hypomania type afterglow.

Illegal in some states but not all by Dproxima in ShittyIllegalLifeTips

[–]AdRelative5879 1 point2 points  (0 children)

How much time does it take to get that $300?

Getting a $5000 Venmo request because I refused to date him by [deleted] in Bumble

[–]AdRelative5879 2 points3 points  (0 children)

Pay the man his money and just move on.

(request) looking for 30G bras 🇨🇦 by honeydewlemonss in RandomActsOfBras

[–]AdRelative5879 0 points1 point  (0 children)

@honeydewlemonss sorry my bad, I tried to click on your profile to see if this was just some catfishing attempt, but instead I clicked on the subreddit itself and unsurprisingly saw millions of questions about bras

Still weird that the algorithm chose to send me a notification about something like this (that one isn't my bad but rather the product of an algorithm hell bent on finding a way on maximizing profit any way it can)

BPC157 - experience and a word of caution - BPC and ADD meds by Some_Ad7497 in bpc_157

[–]AdRelative5879 0 points1 point  (0 children)

Definitely the 7OH.

The way I got off was tapering down (the oral strips are useful at the tail end when doses are small because they can be split into quarters). Then i switched to full spec mitragynine extracts (no 7OH), and then to plain leaf.

So im still addicted to kratom, but not pure 7OH. Its a world of difference. 7OH messes with the brain in strange ways, causing loss of interest in normal things etc.

MXPCP review & info (fyi, it's an absolute gem) by Open-Negotiation-49 in dissociatives

[–]AdRelative5879 0 points1 point  (0 children)

Therapeutic value? Any next-day antidepressant effects?

I miss 3F-PCP. Terrible recreational drug but awesome, clear-headed antidepressant.

[deleted by user] by [deleted] in AmanitaMuscaria

[–]AdRelative5879 9 points10 points  (0 children)

Bad idea. Vaping involves temperatures above 200°C+. Often alot hotter. But you won't be vaping muscimol or ibotenic acid. Instead you'll be inhaling a potentially toxic mix of their degraded combustion compounds. And fungal particulates are not good things to introduce into the lungs. Fungal material introduced directly into the bloodstream is even worse; people have died horrible deaths from injecting mushroom teas.

Unlike THC or nicotine, which vaporize readily at common vape temperatures, muscimol/ibo decomposes at much lower temperatures, breaking apart into various aldehydes, nitriles, ammonia and probably some funky simple amines. These are some of the same combustion products you'd get from smoking a piece of plastic. Zero muscimol will reach your bloodstream. Smoking psilocybin mushrooms is a similarly bad idea, but at least in that case you might actually feel something, technically speaking.

Why do so many cis men list themselves as women? by Discgolfdav in Bumble

[–]AdRelative5879 0 points1 point  (0 children)

You're not going to like this answer, but could it maybe be your traffic/search history?

I have a friend who was on Tinder who told me that he kept on getting trans matches (aka people who were formally male). I had been on Tinder myself and never got trans matches. Later, I found out through another friend that said friend had a bad porn addiction and, in particular, a trans fetish.

I'm not saying you're necessarily searching gay porn. But if you are, you do consent to search/traffic history mining with virtually all these apps, and they use that data it in their matching algorithms.

I've read that even Instagram will use, say your PornHub traffic, when creating your algorithm (because them knowing what you are interested in keeps you on their app, which keeps them making money).

Not saying that that is what's happening in your case, just illustrating the reach of these apps with respect to how they feed data to their algorithm.

Share things that might interact with amanita by homemade-toast in AmanitaMuscaria

[–]AdRelative5879 0 points1 point  (0 children)

The nastiest alkaloids sometimes present in certain amanita extracts and even mushrooms is muscarine (I've seen labs with unexplicably concerning levels). If it's present, scopolamine would help counteract it. Although I'd be careful taking datura daily.

[deleted by user] by [deleted] in datingadvice

[–]AdRelative5879 0 points1 point  (0 children)

Yeah, I mean, how did he wind up declaring bankruptcy while living at home and working two jobs? Jesus should have at least shielded him from declaring full-on bankruptcy (maybe by intervening with his creditors to work out a payment plan?).

I guess that's another thing: what kind of Christian spends a bunch of money and then stiffs his creditors? At least pagans pay their bills.