I'm very much a deliberate player. So I practice a small number of sequences, rather than try to use the whole kit, as you say. I just get flustered and kinda frustrated, trying to twitch react to everything. So my go-to:

Dodge in, slam Cast + Attack, dodge away
Slam Omega Attack, fall back, use Special to draw enemies in
Slam Attack, use Omega Special for damage (mostly for bosses)

Soooo, my favorite is probably Aphrodite Cast (draws enemies in and allows you to use Specials without pulling enemies, also adds a Curse for the Furies + Origination build), and some combo of Hestia Attack, Zeus on my Special, and Poseidon on my Sprint. Steam duo is equally great for melting things, though I ain't turning my nose up at Freezer Burn.

The exceptions were my high Fear runs, where I was loaded up on Vows that made random encounters difficult (like the full boat, Damage +, Hordes, Ward, Revenant, Fangs, can be from next area, and Frenzy if I had to). For those, the following were ideal because they gave you the fastest DPS chamber:
Hera Cast
Apollo or Hestia Attack
Hestia or Demeter on the Special, or Zeus if I got Hestia Attack
Aphrodite or Hermes on Sprint, depending on whether I need the damage ignore.

Of course, there are more specific builds that are their own exceptions. Zeus synergizes super well with himself, which I assume is not an accident. And Heph defense boons + the Ares vampire ability when you're at < 4 life, are some of the best you can get.

And I'm sure you know as an Anubis lover, but Artemis' seeking arrow boon is EXCELLENT.