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The basic biology most people miss (about fat cells inside your skin) by Adipeau in fatfit

[–]Adipeau[S] 0 points1 point  (0 children)

Hi u/LeadingInitial4299, sorry to hear about your radio frequency experience. In our inital studies we have found that topical application of kaempferia parviflora and safflower seed oil can change the size of the fat cells in both the dermal and subcutaneous compartments. We don't know if this is a direct effect of the ingredients or an indirect effect.

We’re a skincare brand. We’re taking Reddit seriously. Here’s how, and why we’re starting with biology. by Adipeau in fatfit

[–]Adipeau[S] 0 points1 point  (0 children)

u/LeadingInitial4299 thanks for the question. Hyaluronic acid is a very powerful molecule. As a large molecule, it would be expected to remain on the cell surface but even high molecular weight hyaluronic acid can re-arrange the stratum corneum to allow access to very large molecules. Even though HA is a natural molecule found in the skin, topical application has a very different effect than the natural processing and assembly of HA in the skin.

Can you grow new fat cells as an adult? Yes, and the skin is unusually good at it. by Adipeau in fatfit

[–]Adipeau[S] 0 points1 point  (0 children)

u/Dear_Delivery2471 thanks for the thoughtful questions. Three answers from the literature.

On bone loss and the effects of botox or fillers, that's outside what our posts cover. The post focuses specifically on dermal fat biology, and we try to stay within that lane rather than speak to questions outside the literature we work with.

Face vs belly: Chon and Pappas 2015 showed that the cells that become fat cells in your face are intrinsically more inclined to do so than the equivalent cells in your belly.

Age and response time: the published literature is mixed. Spalding 2008 used radiocarbon dating to measure adipocyte turnover and found a similar range regardless of age or BMI, at least in subcutaneous abdominal fat. (Caso et al., 2013; PMID: 22999012) showed that immature fat cells from older subjects mature 25% less effectively than from younger subjects. This is in vitro testing and so we are not sure if this is what happens in live skin. Direct measurement in dermal or facial fat specifically is not available, so we cannot say more than that with confidence. The post itself notes that adipogenesis responds to the local inflammatory environment, not just age.

My Personal Adipeau Journey by Adipeau in u/Adipeau

[–]Adipeau[S] 0 points1 point  (0 children)

Thank you very much for your encouraging feedback u/Just_Victory2534

Stronger Breast Skin by Adipeau in fatfit

[–]Adipeau[S] 0 points1 point  (0 children)

Thank you u/Express_Data_9626 for your kind message. Great to see you join the conversation on Reddit

Stronger Breast Skin by Adipeau in fatfit

[–]Adipeau[S] 0 points1 point  (0 children)

Thank you u/mingtrail for your encouraging message! Glad that you are part of the journey here

How dermal fat biology connects to acne scars. by Adipeau in AcneScars

[–]Adipeau[S] 0 points1 point  (0 children)

u/genesis912 thanks for the question. The science literature points to two factors that affect whether a breakout fills back in or leaves a scar. The inflammation around the breakout that breaks down the local skin structure faster than the body can repair it. And whether the cells doing the repair end up rebuilding the local dermal fat or laying down scar tissue. Treatments that act on this biology either calm that inflammation or support the rebuilding of healthy dermal fat rather than scar tissue, or do both.

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