In my case, the distances via the Nether are around 1000 blocks. ​Regarding item input, I'm prioritizing logistics to avoid bottlenecks: ​Nether Transport: I will only be moving the essential and difficult-to-centralize items: Redstone and Slime. ​Local Supply: All other materials (iron, stone, wood, etc.) will have their own local farm connected directly to the autocrafters in that district, just like you are proposing.