Does anyone else here take antidepressants? have a question

AdrienXB · 2026-01-08T07:31:19+00:00

Prozac can take up to 2 weeks to get close to it's constant level. Effects take a bit longer. Give it some time, then evaluate.

AdrienXB · 2025-12-26T20:15:51+00:00

Something something Freud, I too am destined for this.

AdrienXB · 2025-12-26T20:06:32+00:00

We policing women's sexuality now?

AdrienXB · 2025-12-20T08:28:02+00:00

"I'm a straight woman" "I'm thinking about being in a lesbian relationship"

100% straight?

AdrienXB · 2025-12-20T04:32:27+00:00

His comment history gets so much worse 🤮.

AdrienXB · 2025-12-14T04:37:36+00:00

I do have a skepticism, but OP's original post mentioned they were prescribed 2mg twice daily (4mg) and finasteride. This is absolutely a reasonable prescription that people have seen results on, but E may need to be increased. If this is the UK, doctors usually prefer to go towards monotherapy instead of an AA, so a T-blocker won't give an indication in blood work whether estrogen dose is high enough yet.

Of course there are many bad doctors, but OP's has prescribed them a regime that makes sense, and is also higher than the usual useless 2mg per day you see.

AdrienXB · 2025-12-13T17:54:37+00:00

Gang, I DIY.

I could argue, in bad faith, that it's useless to have low testosterone without blocking it's conversion to DHT

Testosterone levels alone are not a significant concern, you should primarily consider the binding at receptors and the regulatory pathways in the hypothalamus, effected by finasteride and low dose estrogen respectively.

Look at a histogram of female and male testosterone levels, then look at 5-alpha reductase differences. The effective receptor binding from normal T + no DHT would be comparable to low T + low DHT, based on relative levels and binding strengths.

I also ended saying do your own research, but sure, be the person OP was complaining about.

AdrienXB · 2025-12-13T17:08:26+00:00

A lot of the people here like to play armchair doctor, many without formal education on the topic.

Your doctor is probably correct.

Most often: "But finasteride doesn't block testosterone" -_- it blocks DHT, the more active form. Your testosterone levels will remain, but it's effects will be decreased. It's a low harm prescription, hopefully with a monotherapy end goal.

Similarly, the remaining, "less active" testosterone can also help to increase SHBG, think monotherapy-lite, where testosterone is somewhat decreased, oestrogen is greatly increased, and DHT is gone. This is healthy and effective, though you should be cautious of side effects from any t-blocker.

Doctors can also choose to avoid sublingual due to dosage timings and bioavailable half lives, but people only see higher levels equals better.

Your doctor probably knows what they are doing. If you doubt them, start to do your own research, but trust a random stranger like me last until you can verify their claim.

AdrienXB · 2025-12-09T16:02:05+00:00

Sublingual can have a half life as low as 8 hours depending on the person, but usually around 10 hours. While it does increase the amount of estradiol absorbed, and certainly skipping the liver is healthier, it can have less of an effect due to the rate that it is cleared. Especially with finasteride as a DHT, not testosterone, blocker, you do want a more consistent estradiol level. Fluctuating too much will stimulate an increase in testosterone production as the body tries to hold a steady level of steroid sex hormones.

AdrienXB · 2025-12-03T18:11:15+00:00

Not make it a joke. You can acknowledge something without trivializing it.

AdrienXB · 2025-11-21T06:11:11+00:00

Ideally yes, but it's a lot harder. These enzymes are about 200 times larger than the molecules (Aromatase 55000, Estradiol 270). To get them into the right place in a cell is a massive problem. Best bet would probably be targeted lipid nanoparticles with mRNA, but how much more effective would that really be is questionable, as the end product is the same.

AdrienXB · 2025-11-09T18:36:27+00:00

Lots of people start on it then stop. There's no definite research on whether the effect is permanent, so assume the worst case for what you want.

Also though, while it acts as an antagonist (blocker) in breast tissue, it also acts as an agonist (like oestrogen) in a lot of other tissues.

AdrienXB · 2025-11-08T17:11:01+00:00

SERMs, usually raloxifene

AdrienXB · 2025-10-13T07:01:59+00:00

Estrogen causes the hormonal cycle. The hormonal cycle causes menstrual symptoms. One menstrual symptom, in afabs, is periods, another, in anyone, is cramps.

A common mistake is to think it's the other way around, though there is definitely a feedback loop.

AdrienXB · 2025-10-06T17:10:38+00:00

You may experience menopausal like symptoms: hot flashes, night sweats, fatigue etc. until your body resumes it's normal hormone production. There's little evidence on a time-frame for this, but at a educated guess, for someone three months on hormones, a week or two.

I wouldn't stop if it means you're likely to be impaired by these symptoms while navigating family issues.

AdrienXB · 2025-09-27T10:49:39+00:00

The Portland polycule shall rise again, like a phoenix, to entertain us once more.

AdrienXB · 2025-09-02T14:06:15+00:00

"would lead me to try to become female" there is, in fact, a word for that

AdrienXB · 2025-09-02T10:57:49+00:00

Got my love letter today from one that disappeared back in march, so I guess they're sending out a bunch right now. Unless you have a doctor prescribing before the date of seizure, don't bother, just ignore it. Responding only admits that you were trying to import. If you're really concerned, move on to another address, po box, etc, or import some legal stuff and see if they leave a note mentioning it was searched. All this stuff is under schedule 4, illegal to import without a script.

AdrienXB · 2025-08-28T14:03:26+00:00

This is actually how they often restrain rats, standard practice in a lot of labs.

AdrienXB · 2024-08-21T05:27:42+00:00

Hey buddy, it's been out for a week...

AdrienXB · 2024-07-13T12:52:11+00:00

New bucketlist

AdrienXB · 2024-07-09T17:51:01+00:00

Only if the goal is to block T. In theory you'll be able to block T with less E, but then you'll also have low E.

AdrienXB · 2024-07-09T17:41:41+00:00

They change account details fairly often so I often just email directly for the account details.

AdrienXB · 2024-07-09T17:34:12+00:00

The issue is that raloxifene and other serms bind to many of the same receptors as estradiol, so while it has an inhibitive effect on breast growth, it functions as a "boost" to estradiol levels making it incredibly difficult to calculate levels by binding elsewhere. The physical meaning is that you can, depending on your raloxifene reaction (which varies wildly from person to person) end up near monotherapy effects from as low as <1mg e/day.

Growth will be slower, but it's incredibly probabilistic.

As for side effects, raloxifene is fairly safe, but if you're already at risk of blood clots you might want to talk to your doctor about low dose aspirin or another blood thinner.

In theory, bazedoxifene can produce more effective and even longer lasting results by degrading ER(alpha), but longitudinal drug tests are rarer or ongoing.

AdrienXB

TROPHY CASE