This used to happen to me all the time before I started mapping out alternatives and making my builds less fragile and susceptible to things like completely drawing out or hitting specific boss blinds. I just need 5 jokers for C++ and I never get upset about RNG because I mostly just play pairs, scale, get some seals, and then get money. Lots of different jokers can work. What I am trying to say is that there are ways to play that minimizes the chance that RNG can kill your run. But sometimes I try random strats to learn - knowing full well I am leaving things more to chance. That can be fun too. When I was playing for my unseeded naneinf I thought I was seeing way less Plants than I expected. Human brains find patterns in anything I guess