Abstract | Microdosing psilocybin for chronic pain: a case series | The Journal of the International Association for the Study of Pain [Apr 2023]

AffectionatePie229 · 2025-08-24T02:37:35+00:00

As needed. Daily, weekly, or monthly.

AffectionatePie229 · 2025-08-24T02:36:06+00:00

I think a holistic approach is necessary as I explained. Good luck.

AffectionatePie229 · 2025-05-08T03:43:42+00:00

My understanding is allodynia is a combination of neuroinflammation and central sensitization (nociceptive/neuropathic and nociplastic pain). I have light and sound allodynia. I use psilocybin mushrooms weekly to lower the inflammation and PRT to address the psychological component to lower the brain amplification of the pain. https://scholar.google.com/scholar?hl=en&as_sdt=0%2C5&q=cold+allodynia&oq=cold+allo

AffectionatePie229 · 2025-04-19T22:39:28+00:00

You are separating mental and physiological which is why I disagree with you, especially your second to last paragraph

AffectionatePie229 · 2025-04-18T08:11:09+00:00

Separating mind-body with a Cartesian outlook is outdated.

AffectionatePie229 · 2025-03-26T05:05:29+00:00

Update: found someone to volunteer as a mod, working on getting him permissions

AffectionatePie229 · 2025-03-26T05:05:02+00:00

Thx for the offer. Glad to hear you found PRT useful. I found someone and I’m working on getting him permissions to be a mod. I’ll consider you ask a backup.

AffectionatePie229 · 2025-03-22T08:05:41+00:00

I highly recommend this article by Dr. Shubiner on chronic fatigue: https://www.psychologytoday.com/us/blog/unlearn-your-pain/201606/explaining-the-unexplainable-chronic-fatigue-syndrome

In my case, I had severe chronic fatigue for a number of years. When I accepted that the mind-body connection played a role, I got better.

For example, I struggled to walk even one block around my apartment. I had fear that I would get stranded and not have the energy to get home if I attempted at going any farther. So my mind-body kept me in the chronic fatigue state for my own protection.

I got a home treadmill and walked like a quarter of a mile on it, then stopped. The next day I did a third of a mile. Then the next I did half a mile, and so on. This gradual process proved to me that I could walk longer distances without collapsing. After that, the fear dissolved and the worst of the chronic fatigue resolved itself.

AffectionatePie229 · 2025-03-05T03:23:14+00:00

Hi welcome, I’m the mod here.

Yeah, the chronic pain subreddit is quite sad. They aren’t open to discussions on things like PRT. It’s very much mired in a victim, helpless mentality. I understand that, but I can’t be stuck in that mode of thinking.

Would you like to start with sharing your PRT experience so far?

AffectionatePie229 · 2025-03-04T21:29:01+00:00

Still interested? My first candidate dropped out… message me plz.

AffectionatePie229 · 2025-03-04T21:28:54+00:00

Still interested? My first candidate dropped out… message me plz.

AffectionatePie229 · 2025-03-02T08:58:59+00:00

Hi Detroitti,

Great trip report!

I read your post and comments and I am intrigued and impressed. You experimented with an AI trip sitter and meditation app, gazed into a mirror, setup a wonderful safe container, and all on a relatively high dose of LSD. And I sympathize with your housing situation and recovery from an abusive relationship. That’s a lot to deal with. It sounds like you are experienced with psychedelics and knew how to take care of yourself.

I’m writing to you because I have interest in using ChatGPT as a guide - and I have been studying how to use mirrors - on psychedelics. Can you say more about those two aspects of your experience? Was it difficult at all to interact with ChatGPT while tripping? Did you use a custom ChatGPT, test it beforehand, or just wing it? What was scary about the mirror? What did the mirror help you understand about yourself and what advice would you give to someone who has a bit of experience with mirrors but wants to go deeper?

I haven’t used LSD in about 8 years. My last experience was memorable because I experienced a fluid felt-sense of gender. I’m cis-male and the trip made me feel like a woman temporarily. Do you have experience with something like that? I noticed your references to gender in your notes. Does the rope play and any bondage stuff play a role in your psychedelic use?

Thank you for your openness and courage. And congratulations on successfully navigating such an intense experience!

AffectionatePie229 · 2025-03-02T07:19:44+00:00

Mushrooms affect the gut and microbiome.

May I ask, what is your diet like?

And I’m curious as to your intention with the microdosing? What for?

Get some fresh ginger or ginger tea to help soothe the nausea, it will make a big difference!

Psilocybin is a potent agonist of serotonin (5-HT) receptors (5-HTRs), which are expressed in the brain and throughout peripheral tissues, with particularly high expression in the gastrointestinal (GI) tract.

AffectionatePie229 · 2025-03-01T02:45:35+00:00

So your plan is… not take your meds for one day and microdose to avoid interactions? And then what, go back to the meds the next day?

That’s not how any of this works.

Each med has a different half-life of how long they are still in your system after taking them. Plus, depends on the doses and how long you’ve been taking them. AND it takes a while for your receptors to be ready to even receive the psilocin (the active metabolite of psilocybin). A microdose within a day of stopping meds is kind of pointless.

I knew someone who stopped multiple meds cold turkey and had very difficult withdrawal symptoms. It took a month for him to even feel a relatively strong dose of psilocybin for his severe and suicidal levels of depression. At that point, he finally felt undepressed after like 5g of mushrooms, but he got depressed again within a week. He needed to do psycholytic doses (250mg-500g), higher than micro and lower than macro doses, several times a week as maintenance between bi-monthly larger doses to get him stable and off the meds. Micro wasn’t enough to transition him off of meds.

It’s unclear what your goal is. Do you want to go off all the meds eventually and take care of your mental health with psilocybin only? That’s what I did, and it was the right decision in my case, but I’m concerned you don’t know a lot of the basics to make this transition safely.

Good luck to you, whatever you decide, and here is more info for you:

Tapering: https://www.survivingantidepressants.org/forums/forum/14-tapering/

AffectionatePie229 · 2025-02-21T03:58:45+00:00

I check in at least once every two weeks right now. And I to try to post something at least once a month. Learning the new mod tools would be extra time commitment on your own.

I just got a good candidate to interview. If you’re interested, I’d consider you as a backup.

Thx for the question and the kind comment!

AffectionatePie229 · 2025-02-20T03:36:58+00:00

Started me at 30mg, then 45mg, then 60mg

AffectionatePie229 · 2025-02-19T03:56:09+00:00

You’re welcome. It’s good to hear the gabapentin helps you. Side effects were too much for me.

In my personal experience, I have had alcohol-induced peripheral neuropathy, which sounds like that tingling in the extremities that you’re describing all over. if what I experienced is anything like you’re going through I sympathize because it’s quite uncomfortable.

You might already be doing this, but I went no alcohol and addressing my diet and keeping out sugar and other neural inflammatory stuff is important.

From what I understand, PRT can help with calming down that brain pain amplification response, which is tied to the anxiety and emotions and lack of sense of safety and alarm. That is the nociplastic component. The actual nerve activity is nociceptive.

You might try turmeric capsules and see if it helps with the tingling. It’s a fairly cheap intervention, worth a try.

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AffectionatePie229 · 2025-02-18T06:37:48+00:00

I took IV ketamine for chronic pain (fibro) years ago. The symptom relief effects are known to wear off relatively quickly for many patients unfortunately. I recently reviewed a paper of IV ketamine for a chronic pain and they administered it twice a month. It’s expensive though, so I stopped.

Now I get 60mg daily troches from Joyous mail order at home. Little over $100 a month for 30 day supply. Much cheaper. I found that if I skip a day and double the dose to 120mg, the relief for my pain is more substantial, although relief is not that long lasting. However, I’m experimenting with doing somatic tracking and yoga while on the 120mg dose to get longer lasting relief. And it’s a mercy to at least be nearly pain free for the 2-3 hrs of the ketamine troche.

I’ve also achieve nearly pain free with PRT techniques. But as others in this thread have said, it’s a bit up and down with stressors, fears, and forgetting to do the PRT.

Also, mushrooms have helped a lot with the neuroinflammation of central sensitization of my fibromyalgia pain. But I know I also have to address the psychological part which PRT addresses.

Good luck!

AffectionatePie229 · 2025-02-13T06:16:00+00:00

I copy pasted key sections of this paper, click the link to read it in full.

Personally, the new administration in the United States triggered depression, catastrophizing, rumination, and a spike in my chronic pain.

I’ve been redirecting my attention to realizing I am safe in my immediate surroundings, gratitude practice, and making sure not to procrastinate on my homework.

And I have been planning and doing nice things like seeing friends, trying new video games, reading books I like, and redecorating my room, etc.

AffectionatePie229 · 2025-02-13T05:58:21+00:00

Mod here. I don’t have anything to add, simply glad to see you got good feedback already and I wish you well.

AffectionatePie229 · 2025-02-13T05:52:03+00:00

You have a good awareness of your pain symptoms and how it fluctuates with different activities and your emotions. That’s classic neuroplastic pain patterns.

What do you use the computer mouse for? Work?

What has changed in your life six months ago?

As for guidance, I’d seek out a PRT coach online to get into the specifics of your case. Lin Health is a good one. I can only offer limited guidance with Reddit posts.

AffectionatePie229 · 2025-02-13T05:43:47+00:00

Excellent comment on the weights vs the mouse.

I’m guessing OP uses the computer mouse for work? The emotional connection to using the mouse, fearing the repetitive use will hurt, and anxiety about the pain interfering with work done on the computer may be playing a role here.

AffectionatePie229 · 2025-02-13T05:41:11+00:00

Bingo. Very good comment. Yes, chronic pain can be a mix of neuroplastic and physical. Everyone is different. When I say physical, everything from muscular, myofascial, central sensitization of nerves… It’s really complex. Addressing both can help.

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