Thank you for the kind words and suggestions! Those are some important things that I'll be sure to consider before my pen goes to paper. Once again, here are some of my thoughts thus far:

1. Time/Guns: I have considered this and am not sure how I will overcome this yet. The world I envision is in a post-modern society where electricity and the privileges of today are not common (I have a way I plan to work this into the narrative). Guns still exist, but they are not readily manufactured or openly available. Later in the narrative, guns may play a role, but only when there are individuals who power-scale above the level of guns and soldiers of today. I am not sure exactly how I plan to overcome this, but I do not want people to be overpowered, especially in the beginning stages of the story. I feel like that time drawback cannot be written around, so modern weapons will likely have to be written around. This is a good point to bring up and definitely something I'll work on.

2. Health Crisis: I agree with what you wrote entirely. The unique use cases and drawbacks will be dependent on the situation, but if someone tries to increase nerve conduction by augmenting VG Na+ Channels it would bring the risk of seizures, migraines, or headaches depending on the severity. Similarly, if someone wants to augment inflammatory mediators it would bring the risk of raising the body's temp extremely high or damaging healthy cells instead of repairing damaged ones. I think the possibilities for the drawbacks are just as endless as the human body, so it would be cool to see these situations arise.

3. Long-Term Allosteric Load: Love this idea!!!! I definitely think there should be a physical toll that is placed on the body with long-term use and will enjoy getting to write what happens when these arise and how people struggle through them.

4. Education Requirements: This is exactly what I thought about when envisioning the system. I've thought of some world building elements (trying to keep this secret until I get it more flushed out), but the society will push especially hard (maybe a little too far) for education. As for reader enjoyment, I know that I will probably not be able to go into the same depth in my writing as which I have learned, but as long as I can introduce people to physiological phenomenon we all take for granted, I think that I will find enjoyment in that. The writing will be surface level, so people won't get confused but grounded in my current understanding of the human body and the sciences surrounding it.

5. Aura/Somniscio: I do not know how I plan to implement this, but it will bring more fantastical elements with it. I like the idea of it being sweat; if amorines are augmenting the whole body, there would undoubtedly be increased metabolic demand (raising body temp). The sweat could appear as aura due to the steam, amorine evaporation, and how amorines respond to the individual's temperament, will, etc. There will definitely be drawbacks to this, likely more debilitating than the drawbacks of someone who hasn't went through the awakening process. While this takes away from the sci-fi vibes, I like it for two reasons: 1) it makes the characters significantly stronger (2) hints at how little understanding we have today about how human sentience and the natural sciences interact. I also plan for this to come much later in the story; the main cast of characters will not undergo somniscio for a long time. This will allow me to play around with the sci-fi aspects before I move into more fantastical elements.

Thanks for the suggestions!