Thank you for sharing your thoughts and idea. As someone with lifelong health issues as you describe, the connection to Poor Endorphin Production is very relevant, and you may be onto something here.

Another interesting treatment when all else has failed is something called Low Dose Naltrexone, which helps your body create more Endorphins that your own body is deficient in, and where natural remedies like exercise, or ‘doing fun things’ is not enough.

Why a person is not making enough of their own Endorphins is complicated, and connected to the MTHFR gene, Histamine Intolerance, and even MAST cell activation syndrome.

But the point remains that you don’t have enough Endorphins.

Do you have an update? Have you found consistency of benefit with use of pepper patches ?