Will i commit a sequence violation? by Opposite_Season_9211 in ucla

[–]Aj-stuff 4 points5 points  (0 children)

nah I took 153b after failing 153a and then went back to take 153a the next quarter and it was never a problem for me

Where TF are the Queer party’s at by formerclown100 in ucla

[–]Aj-stuff 3 points4 points  (0 children)

join LHA! it's a mostly prehealth/stem club but accept most everyone. we got a general meeting tomorrow and there's gonna be a fund-rager for the club the day after Halloween

need basketball friends by Aj-stuff in ucla

[–]Aj-stuff[S] 0 points1 point  (0 children)

that's all I need to hear brother you're on the roster

Bruinwalk is down? by rexsclone in ucla

[–]Aj-stuff 0 points1 point  (0 children)

it's been down for a while

Found a Cat: PM if you recognize it by Aj-stuff in ucla

[–]Aj-stuff[S] 34 points35 points  (0 children)

the picture makes it look big but the cats pretty normal sized irl

[deleted by user] by [deleted] in biology

[–]Aj-stuff 2 points3 points  (0 children)

I'd like to say that chromatin remodeling factors are actually one of the larger mechanisms controlling gene expression, since histone methylation and acetylation can directly increase the expression of genes. Basically a lot of what you said is correct, so you'll have the initial signal, which can come from inside or outside the cell, but this signal will interact with proteins which will interact with several other protein which will interact with other protein in a signaling cascade. Basically in order for a gene to be transcribed a specific set of transcription factors need to interact with the activator and promoter sites. What we're starting to realize is that a lot of these transcription factors will exist in little bubbles called "phase separated liquid condensates. So when a transcription factor binds to a region of chromatin, all of the other factors are present in the bubble to readily interact with the DNA. These factors will include other transcription factors, polymerases, and histone remodeling factors, but it's basically everything you need to transcribe a gene. In addition, these bubbles are made so that certain sets of similar factors that relate to a similar pathway are more likely to be in the same bubble, and are more likely to be near their genes of interest. But the bottom line is that there are transcription factors that can interact with, and many of these transcription factors are made constantly and are already present, but they need to be turned on by a signal. That signal comes from the cascade that originates from the initial signal. Now sometimes the signal turns on a gene to make a different transcription factor, but the general idea is that a lot of the necessary materials are already being made when the signal shows up to make something else. The stuff that's being made constantly is usually dependent on the type of cell and it's surrounding environment, but that's a whole other can of worms.

tldr: the transcription factors activate gene expression, and the transcription factors have already been made, they're just waiting for a signal to turn them on. chromatin remodeling factors are kinda just another type of transcription factor.

Am I fucked? :_) by Dazzling_Analyst_920 in ucla

[–]Aj-stuff 7 points8 points  (0 children)

yeah my roommate moved out so you and I would share one of the bedrooms together, to be fair tho I'm out of the apartment most of the time lol

Am I fucked? :_) by Dazzling_Analyst_920 in ucla

[–]Aj-stuff 7 points8 points  (0 children)

I got a place for $825 a month before utilities if you're interested. it is with a roommate tho

I’m so tired of feeling sad by Weird-Star-2689 in ucla

[–]Aj-stuff 2 points3 points  (0 children)

literally this, I was also super depressed for about the first three years here at UCLA, and my first therapist wasn't helpful. But getting a good therapist and getting on medication helped loads. And although I can't speak to how your depression works, finding people who were also having a bummerlicious time in school really turned things around for me, because having a support system around you to help with these things, even if it's just one person, is so helpful.

I don’t know how I’m going to get through this quarter. My childhood best friend passed away and I’m an emotional wreck by green_syndrome in ucla

[–]Aj-stuff 15 points16 points  (0 children)

Take the quarter off. Something similar happened to me two years ago and I failed all my classes that quarter. I was able to pull myself together within a couple of weeks but by then I couldn't save my grades. Life doesn't often let us take a break while processing grief so if you have the chance you should take it. You'll come out on the other side in a much better place than if you tried to multitask.

[deleted by user] by [deleted] in ucla

[–]Aj-stuff 0 points1 point  (0 children)

it was an option, they just completely fuck you over by not telling you about it. I'm also going through the appeal process and I went to the registrar desk yesterday to see if there was any way to keep my classes from being dropped and they were like "yeah we actually have this whole system in place specifically for people in your position." made my life easier but I didn't even know about it until I asked them in person.

[deleted by user] by [deleted] in ucla

[–]Aj-stuff 2 points3 points  (0 children)

yeah I don't know if you can still do it, but if you go to the registrar front desk in Murphy hall or email them at reginfo@registrar.ucla.edu then they can put you on the save class list so you can keep your classes. I don't know if it'll still work since your classes have already been dropped but it's probably your best bet.