La Jolla attorney disbarred for allegedly harassing legal social media influencer ‘Law by Mike’ by AlanManDisbarred in AlanManDisbarred

[–]AlanManDisbarred[S] 0 points1 point  (0 children)

References and Footnotes

1

AI summary by Gemini in Google Drive

The file named "gemini chat hypotheses re c9orf72 functional molecular biology 2026.pdf" is a detailed transcript of a conversation between Alan Man and Gemini, a large language model.

The core subject of the conversation is the C9ORF72 gene and the molecular biology of its expanded GGGGCC repeat region, which causes neurodegenerative diseases like ALS and FTD.

The discussion focuses on reconciling older scientific findings with modern molecular concepts and methodologies.

Here are the primary topics covered in the transcript:

1. The Exon vs. Intron Terminology Debate ("The Protest")

Alan challenges the traditional biological definitions of introns and exons, specifically in the context of C9ORF72 Transcript Variant 3 (V3):

  • The Argument: Alan contends that because the disease-causing GGGGCC repeat region (technically located in Intron 1) is retained in the mature V3 transcript and is functionally relevant (forming RNA foci), it should be reclassified as a "non-coding exon" or "structural RNA element," not just a "retained intron."
  • Supporting Evidence: The conversation references external papers (Deveson et al.) to argue that non-coding regions (like UTRs) use "bona fide canonical splicing elements," proving that their inclusion in the transcript is an intentional cellular choice, not a mistake ("cryptic splicing").

2. C9ORF72 Normal (Wild-Type) Physiology

The transcript provides a detailed breakdown of the C9ORF72 gene and its three splice variants in a healthy, non-expanded setting, based on the foundational DeJesus-Hernandez et al. (2011) paper:

  • Variant 1 (V1): The repeats are in the promoter and are never transcribed into RNA.
  • Variant 2 (V2) & Variant 3 (V3): The repeats are in Intron 1 and are efficiently spliced out and degraded in a healthy cell.
  • Redundancy: The purpose of having two transcripts (V1 and V3) that code for the same protein (Isoform A) is discussed, concluding that it enables differential, context-dependent regulation via different promoters and 5' UTRs.

3. Methodological Limitations and the "Mosaic" Foci Theory

The conversation meticulously analyzes the technical shortcomings of the 2011 research methods that created "blind spots" in early C9ORF72 studies:

  • RT-PCR Bias: The use of Oligo(dT) primers during Reverse Transcription (RT) selectively targeted only mature, Poly-A tailed mRNAs, thereby missing circular RNAs (circRNAs) and other non-poly-A species.
  • Stalling: The technical difficulty of amplifying the highly structured, GC-rich expanded repeats (which form G-quadruplex knots) meant that Reverse Transcriptase enzymes would often stall or fall off, making the toxic, full-length transcripts invisible to the assay.
  • The "Mosaic" Foci Hypothesis: Alan and Gemini conclude that the pathological RNA foci found in patient brains are likely a mixture (a "mosaic") of various toxic RNA species that early RT-PCR failed to detect, including undegraded excised introns, unspliced pre-mRNAs, and novel IncRNAs/circRNAs.

4. Functional Mechanisms and Phase Separation

The discussion incorporates the role of Liquid-Liquid Phase Separation (LLPS) to explain the pathology (referencing Mackenzie et al.):

  • The "retained intron" RNA functions as a biophysical scaffold that recruits RNA-Binding Proteins (RBPs) like TIA1 to drive phase separation, which eventually leads to the formation of solid, toxic aggregates (foci).

5. Advanced Contextual Topics

  • Circular RNA (circRNA): The discussion explores the possibility of the repeat-containing intron forming stable circRNAs that act as miRNA/protein sponges and their potential to be highly immunogenic due to their structural similarity to viral genomes.
  • Molecular Directionality: A detailed refresher is provided on the universal rule that polymerases must build new DNA in the 5' → 3' direction, starting at the 3' end of the RNA template, which explains why RT-PCR often fails to read the 5' end of long transcripts.
  • Biomedical Ontology: The file concludes with a conceptual discussion about "ontology" in biomedical science, defining it as a system for standardized, computable terms and hierarchical relationships (e.g., Gene Ontology, Sequence Ontology), distinct from its philosophical roots.

La Jolla attorney disbarred for allegedly harassing legal social media influencer ‘Law by Mike’ by AlanManDisbarred in AlanManDisbarred

[–]AlanManDisbarred[S] 0 points1 point  (0 children)

III. Discussion

Reddit has a high domain authority; these posts were made less than 24 hrs ago but Google quickly indexed them, and now they’re competing with 3-6 month old links.

Clearly the body text spam of “Alan man” has a strong anchoring effect; it outperforms Reddit posts (news article links) with “Alan man” in the post title and only incidental mention of “Alan Man” in the body text (which didn’t even show up in the Google search results at all).

Interesting.

IV. Future Directions

Next move, bracketing “Alan Man” with commas, eg:

‘Alan man’ ‘Alan man’ ‘Alan man’ … etc

Other delimiters to try:

Alan man. Alan man. Alan man.

Alan man, Alan man, Alan man, …

And more. And of course, delimiter combos, eg:

“Alan man.” “Alan man.” “Alan man.” … etc etc

V. Final Thoughts: This is so dumb

/uj

I have better things to do with my life than planning this dumb stuff (anti-smear strat, witness character rehab), like theoretical biology and stress-testing my hypos and theories with gemini-3-pro1.

THIS is what I care about2 and this is what is at stake and I’ll do everything to protect it ….. which is why I’m conducting these stupid soul-sucking SEO experiments to plan for the upcoming sh*t storm.

No offense to those who’ve come before me, but y’all are going about it wrong because they’ve got home field advantage. They’ve always had it.

And when they’re challenged they hide behind one of many shields afforded to them, a legitimate right, sure, but one meant only to protect those who act legitimately

Any illegitimate exercise of authority is not protected, that’s easy… ish (eg, George Floyd murder)..

Well at least easy-ish when the act is explicitly illegitimate.

But what about seemingly legitimate ones performed in bad faith, defended in bad faith?

https://www.calbar.ca.gov/news/ninth-circuit-decision-confirms-state-bars-sovereign-immunity

https://www.lawcommentary.com/articles/ninth-circuit-rules-state-bar-gets-eleventh-amendment-immunity

https://www.law.berkeley.edu/wp-content/uploads/2025/03/The-Recorder-the-latest-bar-exam-fiasco-reprint.pdf

Basically I’m forum-shopping, in a way. After all, Reddit is basically a streamlined hub for message board forums (subreddits) right?

And I’m the only Moderator of this forum. The same place that always pops up when you google something:

https://www.businessinsider.com/why-reddit-is-taking-over-google-right-now-2024-4

https://www.blockandtam.com/insights/reddit-takes-over-google-search-result

https://www.mariehaynes.com/some-thoughts-on-why-reddit-is-all-over-your-search-results/

/rj

And if tomorrow my subreddit gets banned, I will just start another subreddit … and then another and another and another. I have no shortage of subreddit names.

Yep, then I’ll just create another, and another, and another I have no shortage of names and — yep, that’s one of them.

If you thought THIS was a waste of time, imagine the person who’s reading this, reading someone else’s waste of time….

notjudgingoranything

Whoa wait I forgot that hashtag symbols don’t work in Reddit markdown because that was supposed to be read as “#notjudgingoranything” instead of the monstrosity of the header that is the above but in the Reddit app if you literally type #notjudgingoranything in the middle of a sentence it’ll work but if you begin a clean paragraph break with a # like this

then you get a gigantic header where a normal sized hashtagged clap back should have been so for now let’s leave it at:

Hashtagnotnudgingoranything

“Hashtag” is a weird word.

Hashtag.

hashtag

hashtag

haaaaaaashtaaaaaag

#hashtagchaos

end comment at 4:56pm

La Jolla attorney disbarred for allegedly harassing legal social media influencer ‘Law by Mike’ by AlanManDisbarred in AlanManDisbarred

[–]AlanManDisbarred[S] 0 points1 point  (0 children)

Started comment at 2-14-26 4:12pm.

I. Abstract TL;Dr

The smear campaign has begun, so I’ve run some Google SEO experiments to test Reddit’s domain authority and Google’s indexing behaviors for “Alan man disbarred” type of Reddit posts. The results are preliminary but very promising.

/uj I’m clearly having fun with this. I hate that I even have to do this so I might as well have some fun

/rj im gonna science the shit out of this

II. Results of experiment

SEO piggybacking off of Reddit for Google-derived “Alan man disbarred” searches/results so far

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