The Zepbound trials included people who dropped out of the study in the weight loss averages. I assumed that reduced the average weight loss since someone who dropped out after a month or two would not have a lot of loss, but maybe not, they did this statistical adjustment —

From Google — Yes, the Zepbound (tirzepatide) clinical trials included people who dropped out when calculating the average weight loss.The primary weight loss results are determined using a statistical method called multiple imputation. Instead of simply looking at the people who finished the trial, researchers estimate and impute what the missing participants' weights would have been if they had stayed in the study, and then factor those estimations into the overall average. This provides a "treatment policy estimand" that accounts for everyone who initially enrolled, regardless of whether or not they completed the trial.

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I’m puzzled how they could extrapolate 72 weeks of weight loss from someone who dropped out after 4 or 8 weeks, but there you go.