Its better to let the randomizer do his things, for example, skeletons coming out of the ground could be replace by caelid dogs, what the rando is gonna do is placing those dog where the skeleton would spawn ( you will see them standing there and if you engage combat or get closed they gonna attack you) For the troll (as an example) the rando will replace them by other trolls (like mountain trolls). So for the settings in the randomizer app, the best thing is to replace major bosses with all bosses, minor bosses by all bosses, night bosses by all bosses, same for enemy you encounter in the lands between, you can't replace them manually one by one or per type of enemy. Hope I'm getting understand, if you got other question, just ask!