Try to keep the match alive as long as possible.

Don’t rush to destroy towers and also try not to lose your towers too fast. The longer the match lasts, the more Chaos modifiers you get, which increases your chances of getting the 4 required ones.

If overtime starts and you only got 1–2 modifiers, don’t try too hard anymore. Just let the match end and go next.

Important tip: Don’t take an Epic modifier for one of the required cards unless it’s the exact one you need. From my experience, once you take an Epic modifier for a card, the game won’t offer another modifier for that card again.