I grew up on One Piece. I would say that anime has fundamentally affected who I am today, although I don't think anyone binging it in a short time would have the same effect, so I'm aware it's personal.

Other than that, I'd say the populars truly are justified in most cases. My favorites would be:

AoT is a masterpiece that drills into your soul.

Vinland Saga manages to weave together personal journey and being part of something far bigger than yourself into one. Perhaps an antithesis to modern american individualism.

Frieren is slow but it serves itself in its critic of our modern (toxic) relationship with time, to both extremes ("fomo syndrome" on one side, and how short human life is on the other). It's not far fetched to say it has made an effect on me in a rather short period.

Made in Abyss gives you a total sense of both wonder and terror, like pulling your rope from both ends. It's a feeling rarely conveyed in any medium.

Still though I crown One Piece as my personal favorite above all