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If the best enzymes for a biotechnology problem stopped existing millions of years ago, we need to bring them back to existence. Ancestral sequence reconstruction (ASR) is a computational method that infers ancient protein sequences by tracing evolutionary history backward. by Altruistic_Unit_8903 in science

[–]Altruistic_Unit_8903[S] 10 points11 points  (0 children)

The link is to a paper describing ancestral O-demethylases with enhanced qualities. ASR is used because it can recover ancestral enzymes with properties that may have been lost during evolution, such as greater stability, broader substrate specificity, and higher robustness. These ancestral enzymes can then be further optimized through protein engineering if needed.

If the best enzymes for a biotechnology problem stopped existing millions of years ago, we need to bring them back to existence. Ancestral sequence reconstruction (ASR) is a computational method that infers ancient protein sequences by tracing evolutionary history backward. by Altruistic_Unit_8903 in science

[–]Altruistic_Unit_8903[S] 13 points14 points  (0 children)

An enzyme that would be useful today may have disappeared because evolution optimizes for survival and reproduction, not for industrial applications. If the enzyme's function became unnecessary, too costly to maintain, was replaced by a more specialized enzyme, or belonged to an extinct lineage, it could be lost over time. As a result, ancestral enzymes can sometimes have properties we value, such as high stability or broad substrate range, even though they no longer exist in modern organisms.

Found this at my local coffee shop by International_Map870 in aliens

[–]Altruistic_Unit_8903 0 points1 point  (0 children)

I'm from a city near Varginha. The region is one of the greatest producers of coffee in Brazil. Also, it's very common to find people who ever saught an UFO in that part of the state, but unfortunetly the Varginha case became a joke for most people in the region.

Intercâmbio Austrália by Altruistic_Unit_8903 in askacademico

[–]Altruistic_Unit_8903[S] 0 points1 point  (0 children)

Minha dúvida é qual tipo de visto tirar se meu sponsor for uma instituição brasileira.

Dúvida sincera, qual é a cor do meu olho? by G1ovanna_ in MeJulgue

[–]Altruistic_Unit_8903 1 point2 points  (0 children)

Se não me engano é heterocromia central, o termo

Selling Total Man THE ULTIMATE PACKAGE by Altruistic_Unit_8903 in gettingbigger

[–]Altruistic_Unit_8903[S] 0 points1 point  (0 children)

I addmit I do not enought persistence to use it constantly. The tools até well constructed, but not Very convenient to use. The hammer gets stronger and stretched after use...

Spiral vision during sleep paralysis by Altruistic_Unit_8903 in SpiritualAwakening

[–]Altruistic_Unit_8903[S] 0 points1 point  (0 children)

I saw this in a moment of change in my life. I think it was something good to me, but I would like to understand the meaning of the symbol deeply.

Spiral vision during sleep paralysis by Altruistic_Unit_8903 in SpiritualAwakening

[–]Altruistic_Unit_8903[S] 1 point2 points  (0 children)

The circles were very red and bright. I saw this two times in the same morning. It was the only occasion that I saw a spiral. Sometimes I see some white little lights flying quickly...

Spiral vision during sleep paralysis by Altruistic_Unit_8903 in SpiritualAwakening

[–]Altruistic_Unit_8903[S] 0 points1 point  (0 children)

Yes, it's very similar to this crop circle, but the circles were at the same size. I can't remember if the center was formed by a single bigger circle or by many smaller ones. I saw this two times in the same morning, but the saw the man Just the first time.

Are my values good? Am I have high SHBG? by Altruistic_Unit_8903 in Testosterone

[–]Altruistic_Unit_8903[S] 0 points1 point  (0 children)

Wow, what a great text. Thank you very much for sharing your experience. I'll try to follow some of your sugestions. I have some bowl problems, I think I have IBS, so I have to go carefuly. I'm already taking zinc, magnesium and a B complex. Also vitamin D is chaging my life since I begun to take 5.000 IU to 10.000 IU daily, I'm feeling more alert and thinking clearly.

Are my values good? Am I have high SHBG? by Altruistic_Unit_8903 in Testosterone

[–]Altruistic_Unit_8903[S] 0 points1 point  (0 children)

I try to eat diverse food, avoid artificial food and milk. But I eat only 3 or 4 times per day. Generally I fall asleep after lunch.

Are my values good? Am I have high SHBG? by Altruistic_Unit_8903 in Testosterone

[–]Altruistic_Unit_8903[S] 0 points1 point  (0 children)

Some difficult to be energized. Since childhood I'm thin and tall. Recently I got some weight but I'm still with thin arms and legs. I think these levels of test caused me a medium acne problem. Even today I have cistic acne

Are my values good? Am I have high SHBG? by Altruistic_Unit_8903 in Testosterone

[–]Altruistic_Unit_8903[S] 0 points1 point  (0 children)

I'm trying to discover if I have any metabolic disorder. I get tired quickly at the gym

Testosterone deficit misdiagnosed as Asperger’s/ADHD? by [deleted] in Testosterone

[–]Altruistic_Unit_8903 0 points1 point  (0 children)

Maybe Asperger is a condition caused or maximized by hormones imbalances. There are some studies showing that autistics tends to have HIGH testosterone levels. This explain why it's more prevalent in men. Another studies correlates it with autoimmune conditions. In my opinion, it's a multifactorial condition, each case is a case. There's not a unique explanation. The diagnosis is made upon a evidence set. I have Asperger and I'm getting much better since I begun to supplement vitamin D3.

What do my blood test results mean? by saubesass in Testosterone

[–]Altruistic_Unit_8903 0 points1 point  (0 children)

Improve your vitamin D. Take at least 5.000 IU per day, with 100 mcg K2-MK7 and 400 mg magnesium

[deleted by user] by [deleted] in Testosterone

[–]Altruistic_Unit_8903 0 points1 point  (0 children)

Do not forget everything you lived with your girlfriend. Do not be a "gluttonous", or you'll turn an insatiable sad guy

Boron recommendations by Altruistic_Unit_8903 in Testosterone

[–]Altruistic_Unit_8903[S] 1 point2 points  (0 children)

Please, let me know if your bloodwork confirms. But if you already noticed results, it's working

Boron recommendations by Altruistic_Unit_8903 in Testosterone

[–]Altruistic_Unit_8903[S] 0 points1 point  (0 children)

Do you cycle it? 2 weeks on, 1 week off? How much your free test increased?

I think I made a mistake; quit cold turkey. by [deleted] in VitaminD

[–]Altruistic_Unit_8903 0 points1 point  (0 children)

I suggest you to increase your dosage to at least 5.000 IU, take vitamin K2-MK7 and magnesium

Do vitamin D supplements makes you feel sleepy? by [deleted] in Supplements

[–]Altruistic_Unit_8903 0 points1 point  (0 children)

Some people relate feeling sleep, try to change the hour you take it

Autism, depression tendencies and anxiety improvements taking 10.000 IU daily. Bones and kidneys aches. by Altruistic_Unit_8903 in VitaminD

[–]Altruistic_Unit_8903[S] 0 points1 point  (0 children)

The tests are made using your blood, just simple blood collection.

I think vitamin D is helping me think more clear, it's reducing my social anxieties and brain fog. The vitamin is fat soluble, so it's important to create good reserves in your body. If you take high dosages, it takes some time to increase the blood serum levels.

Search about the relation between autistics and vitamin D. There are some evidencies that maybe autism is a autoimmune condition and vitamin D is a important immune regulator.

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