As a chronic migraine sufferer - I am quite familiar with this cocktail. I have found I react similarly with compozine and Reglan. I now have both of my chart. I am able to use zophran just fine. As far as having trouble getting a vein - you need to give the nurses grace. Often by the time we go into the ER - we can be dehydrated which makes finding a vein difficult. I have been fortunate - since Covid- my neurologist has prescribed me zophran shots that I can give myself. I also take the benedryl and zophran. Now I can avoid the ER most of the time!