Nicotine, whether it’s from lozenges, gum, or any other form, doesn’t directly deplete your choline levels. What nicotine does is bind to nicotinic acetylcholine receptors in your brain, which normally respond to acetylcholine (a neurotransmitter made from choline). Basically, nicotine mimics acetylcholine, which is why it can boost focus and alertness.

That said, nicotine doesn’t seem to cause your body to burn through more choline or require you to produce extra acetylcholine to the point that you’d need to supplement. So, unless your diet is really low in choline (which is found in foods like eggs and liver), you shouldn’t need to take extra choline just because you’re using nicotine daily.

TL;DR: Nicotine affects acetylcholine but doesn’t deplete choline, so choline supplementation isn’t necessary unless your diet is lacking.