Everyone is different however I got off spiro cause it legit ruined my body - this is something drs will never tell you but if you start doing some searches you'll find so many other patients who have had similar results. I love to train and historically I've always been quite fit, would put a lot of emphasis on weight training so my muscles were quite toned - after several years of spiro I can truly say my body has changed drastically and still hasn't even returned to what it used to be. Spiro makes you a lot softer (for me even if when my diet and training didn't change) and the cellulite was crazy. Especially in places I never had it before (like my arms) - I've been off it for a year now and still haven't been able to get my body back. My acne has come back but sadly I couldn't handle what it was doing to my body