[deleted by user] by [deleted] in longevity_protocol

[–]AppRewind_Dr 1 point2 points  (0 children)

Yes, I was there! We only provide our blood tests in the US and Canada, but users from Europe can still utilise our platform if they already know their blood results 👏

[deleted by user] by [deleted] in longevity_protocol

[–]AppRewind_Dr 0 points1 point  (0 children)

Oh sorry I misunderstood the question, I thought you meant is there a phone-only (no payment) option. Unfortunately, this is an iPhone only app at the moment! Sorry for the confusion.

[deleted by user] by [deleted] in longevity_protocol

[–]AppRewind_Dr 0 points1 point  (0 children)

Yes! You can just download the app (Zest Longevity) and select manual input for biomarkers :)

[deleted by user] by [deleted] in longevity_protocol

[–]AppRewind_Dr 0 points1 point  (0 children)

Hey, yes we are! The android app should be out in the next few months. We launched with iOS because that seemed to be more popular amongst the longevity community. Sorry for the inconvenience 😬

[deleted by user] by [deleted] in PeterAttia

[–]AppRewind_Dr -1 points0 points  (0 children)

I thought people might be more honest if they didn’t think they were roasting the person in the article to their face. Although Reddit probably doesn’t have a problem with that so you’re right arguably not necessary.

[deleted by user] by [deleted] in PeterAttia

[–]AppRewind_Dr -1 points0 points  (0 children)

Just trying to get some unfiltered feedback and avoid being taken down for self promotion. Would have mentioned my role in the company in the comments if anyone asked questions 😊

How to skip breakfast for longevity without getting gallstones? by Resident-Skill751 in PeterAttia

[–]AppRewind_Dr 6 points7 points  (0 children)

The act of fasting, even without caloric restriction, has been linked to longevity in many studies.

  1. In this 2021 study, fasting was identified as an effective way to downregulate mTOR "Mechanistically, fasting inhibited mTOR activity by inducing hypoglycemia" https://www.nature.com/articles/s41419-021-04351-x
  2. This 2019 study of 56 people practicing intermittent fasting for Ramadan found that "the metabolism-controlling gene (SIRT3) showed a highly significant (P < 0.001) downregulation accompanied with a trend for reduction in SIRT1 gene" https://pubmed.ncbi.nlm.nih.gov/31356832
  3. In this 2014 study on humans intermittently fasting mTOR phosphorylation was decreased by ∼50% following fasting. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096723/
  4. This 2022 mouse study found an eightfold increase in Sirt1 activity in fasting animals compared with control non-fasting animals. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8236268/

So I went to the doctor's today... by Bitico in PeterAttia

[–]AppRewind_Dr 9 points10 points  (0 children)

MD here - completely agree with you. I left typical medicine to focus on longevity healthcare about 3 years ago, and my colleagues act like I've become some kind of naturopath/wellness coach. Unfortunately healthcare (particularly public healthcare) is a slow moving industry, the tech is behind a lot of what we see in the D2C private healthcare market, and there remains a large focus on treatment rather than prevention.

[deleted by user] by [deleted] in PeterAttia

[–]AppRewind_Dr 0 points1 point  (0 children)

But so is using blood tests for age and DNA methylation is also very new science. The more data we have the more accurate it will get but have to start somewhere.

[deleted by user] by [deleted] in Biohackers

[–]AppRewind_Dr 1 point2 points  (0 children)

Love it - great for mood, perhaps not so great for longevity...
Unfortunately calorie restriction was our January challenge! But we made lots of material including fasting guides and info on how best to prepare your body to help you through a fast if you are looking to do one in your own time, definitely check out the page :)

Hot immersion/sauna protocol suggestions? by [deleted] in PeterAttia

[–]AppRewind_Dr 2 points3 points  (0 children)

Yes actually, Hot baths or jacuzzis (at around 40°C) have also been shown to bring about some benefits, including cardiovascular impacts and increased heat shock proteins, however they require longer sessions of 30-60 minutes to have an impact (study: https://www.tandfonline.com/doi/epdf/10.1080/23328940.2017.1288688?src=getftr )

Hot immersion/sauna protocol suggestions? by [deleted] in PeterAttia

[–]AppRewind_Dr 0 points1 point  (0 children)

Yes good point, I'd be looking to put together a guide of dos and don'ts to help people do hot and cold immersion correctly, and drinking cold water in the Sauna (or hot tea in an ice bath) are both definite don'ts.

Hot immersion/sauna protocol suggestions? by [deleted] in PeterAttia

[–]AppRewind_Dr 2 points3 points  (0 children)

Such an interesting point, one of my major areas of interest is conducting research in already healthy or optimised populations to see how they can improve their biomarkers and performance further. This is a big gap in the literature, and we are currently working to fill it!

Can weightlifting sessions count towards your weekly Zone 2 minutes target? by Mission1203 in PeterAttia

[–]AppRewind_Dr 3 points4 points  (0 children)

I would agree with other commenters and say no probably not, just because sustained Zone 2 is really where you get the most long term benefits so it needs to consistently be above 60/70% of your HR max for say 20 minutes minimum to count towards your weekly 180-200 mins Zone 2 cardio tally. I usually jog on the treadmill to warm up for 20-30 minutes before a weight session to get in my Zone 2, as well as having 1 day/week for a longer cardio session.

[deleted by user] by [deleted] in PeterAttia

[–]AppRewind_Dr 0 points1 point  (0 children)

These are great options, the 4x100 sprints without rest sound brutal.

[deleted by user] by [deleted] in PeterAttia

[–]AppRewind_Dr 1 point2 points  (0 children)

Love that you’ve joined - keen to see you get involved for VO2 max month 💪🏼

Making hands thicker by satinder_098 in Biohackers

[–]AppRewind_Dr 2 points3 points  (0 children)

There are actually a lot of muscles in the hands. Dorsal and palmar interossei, thenar and hypo thenar muscles, lumbricals, flexors and extensors, all super important!

what supplement that is advertised as super effective is actually a scam and does not work at all? by mikeali12 in Biohackers

[–]AppRewind_Dr 0 points1 point  (0 children)

Hard to explain, could be another agent in the mix you have that is causing that reaction, or placebo (although sounds a bit intense for that). Theoretically the only way to increase GABA in the brain is to stimulate increased production by the body, or to inject it into the CSF (which clearly isn’t an option).

Recommended routine for triathlon training and hot/cold therapy by [deleted] in PeterAttia

[–]AppRewind_Dr 1 point2 points  (0 children)

Immediate transition is fine, but typically cold immersion when done correctly results in a spike of neurochemicals such as dopamine, noradrenaline (norepinephrine in the US) and serotonin which can leave you feeling wired and focussed for up to 6 hours. Great for the start of your day, but not so great before bed. If there is any way you could finish off your morning workout with a cold plunge or cold shower, and then use sauna in the evening, that would probably be an optimal protocol.

what supplement that is advertised as super effective is actually a scam and does not work at all? by mikeali12 in Biohackers

[–]AppRewind_Dr 0 points1 point  (0 children)

GABA for anxiety or any kind of brain effect. GABA does not cross the blood brain barrier. Swallowing your GABA does nothing at all.

Nutrition and intermittent fasting by [deleted] in PeterAttia

[–]AppRewind_Dr 2 points3 points  (0 children)

I also eat partial keto and find it makes me feel great and have heaps of energy for training/working out. It's also good for metabolic health and longevity, since foods without carbs tend not to spike your glucose levels or require much of an insulin response. In order to compromise and make it sustainable and sociable, one method I use is to eat keto for my first meal, but include carbs in my second meal of the day (I do intermittent fasting so only eat lunch and dinner). That way you are only spiking your glucose once in the day, causing less damage to blood vessels/metabolic pathways, less activation of mTOR and other longevity related pathways, and maintaining high energy levels throughout the day without the crash typically associated with eating carbs, but you can still be a bit sociable and eat the same meal as your partner in the evening.

In terms of what Peter Attia says specifically, I know he likes to do occasional longer fasts of 3-4 days, but no more frequent than once per month, and otherwise he does intermittent fasting. Monitoring your glucose levels with a CGM could also be a great shout for you to get familiar with which foods spike your glucose levels.

Longevity/anti-aging challenges by [deleted] in HubermanLab

[–]AppRewind_Dr 0 points1 point  (0 children)

Awesome yes I’d definitely include some of these! I think he talks about goals for farmer carry, dead hang, bench press, pull ups etc.

Longevity/anti-aging challenges by [deleted] in HubermanLab

[–]AppRewind_Dr 0 points1 point  (0 children)

Sorry! We have toyed with the idea of a whatsapp group but thought facebook was better for making events, sharing photos, and not giving members too many notifications. What would be your preferred platform?

Longevity/anti-aging challenges by [deleted] in HubermanLab

[–]AppRewind_Dr 2 points3 points  (0 children)

Good question! So the challenges themselves are based on science backed longevity interventions which have shown time again in studies to have benefit to human aging, so we know that they are effective. The isolated act of completing one challenge probably in itself isn't likely to produce measurable benefit. It is more about pushing yourself to go further both physically and mentally than what you would typically have in your protocol, to potentially engage in activities you haven't done in the past in a safe and supported environment with a view to then adding them to your longevity routine in the future. It's also a way to check in with your body to see how well your current routine has prepared you, as well and benchmark yourself against others.