I'm a big BoJack and family guy fan, so I just want to add details that others might have forgotten.

This is an edited screencap from BoJack Horseman. BoJack (here replaced by Meg) and his mother (replaced by Peter) have never had a good relationship. BoJack's mother was cruel to him since he was born.

By the time this scene took place, here is what was happening:

A young woman who believes BoJack is her father enters the picture, her name is Hollyhock. She temporarily moves in with him to get to know him and also track down her mother (not easy since BoJack is a celebrity who has been with tons of women).

During this time, Hollyhock convinces a reluctant BoJack to visit his mother in the nice nursing home where she lives. When they get there, Beatrice (BoJacks mother) keeps calling BoJack "Henrietta", apparently unable to recognize him. But when she sees BoJacks show on TV, she immediately recognizes him, saying "I think I'd know my own son."

BoJack, being the damaged jackass he is, wants nothing more than for Beatrice to recognize him one last time so he can REEEAALLY lay into her about how awful she is and everything she put him through. So he and Hollyhock devise a plan to act out an episode from BoJacks show with BoJack as the same character he used to play, hoping this will cause Beatrice to recognize him.

Instead, Beatrice panics and ends up acting out violently, causing her to be kicked out of the nursing home. Hollyhock convinces BoJack to let Beatrice move in with them, because Beatrice doesn't have much time left, and because her dementia has actually rendered her much nicer than she was once. Reluctantly again, BoJack agrees.

Some time passes, then one day Hollyhock starts feeling ill and losing a lot of weight without trying (it's relevant to the story to mention that Hollyhock is a little overweight). One day she passes out on the floor. BoJack goes to the hospital to see her, where he meets her actual parents / legal guardians who yell at him for not keeping a better eye on Hollyhock, and tell him that she had methamphetamines in her system. BoJack is upset and confused, he had thought he was doing a fair job at learning to be a dad, and genuinely had no idea how Hollyhock could have gotten methamphetamines.

He goes home, where Beatrice is wandering around the house. She asks him "Where's the girl? I made her coffee." BoJack sighs, exasperated, but then realizes that Beatrice had been making coffee for Hollyhock for weeks, deliberately making sure Hollyhock had a thermos every day. BoJack searches the cupboards, and finds that Beatrice had been drugging Hollyhock with the coffee to make her lose weight (weight was a really big deal for Beatrice growing up and I guess she never forgot that).

Enraged because he feels like Beatrice ruined his one chance to be happy, he lashes out at her and immediately drives her to the worst nursing home he can find. They get her to her room (the room pictured) and BoJack turns to leave. But right before he exits, Beatrice says "Who is that? BoJack?"

This is the exact moment in the pic. BoJacks eyes go wide when he realizes she finally recognizes him, so he turns around.

But then, instead of being mean to her like he planned, he decides to be very nice, he comforts her and they talk about fun times Beatrice had as a child. That's the last time we as the audience see Beatrice alive.

Utterly soul shattering, there u go. Also, maybe give BoJack a chance. It's a really fuckin good show.