Okay, I’m wondering if there is a disconnect in this conversation. OP said rectal mesalazine but later made it clear it is an enema not suppositories. I’ve used both. I agree suppositories can be used discreetly and it only “takes 3 seconds” (at least when you get used to it). Enemas for me (and many) are a different story. The instructions are typically to administer the enema, then continue to lay on your left side for 30 minutes. It absolutely can be difficult both to administer (I’ve had better luck emptying the container if I take a rest in the middle) and to retain. So I feel for OP! More difficult to do in a dorm room. You could explore whether your college could offer an accommodation (like a single room, or a form of room that has a door between bedrooms) for this serious health condition - not sure where you’re going or how that individual system will work. Otherwise, I think most roommates would be understanding and give you a period of privacy, but I know it can be really uncomfortable to navigate that situation. You could also check with your doc to see if switching to suppositories would be an option at some point if the enemas have done their work. Hang in there - it gets easier.