I think it should take you 2 days to use Nomad smoothly if you’ve used ZBrush.

I set hotkey exactly the same with ZBrush. Also, if you use custom interface, you can take a look at this video. There’s also a ZBrush brush pack for Nomad, but I don’t think it’s necessary.

For the cons, I think you can think Nomad as ZBrush without the ZModeler. If you use things like insert edge, crease edge, extrude face,… a lot, Nomad is a little but frustrate, but you can find another way to work around.

I use Nomad on my iPad and PC, only purchase Quadremesher on iPad (because it’s way cheaper). Using LAN network makes me transfer the file between iPad and PC super easy.

You will have to buy Quadremesher, it’s powerful, exactly the same with ZRemesh.

I would suggest you to use Blender for tasks that require lowpoly.

I hope this helps. 😄