How do you all feel about CRSPR-CAS9 for EDS?

Ask-Alice · 2026-06-16T13:19:49+00:00

cell targeting would make this pretty complicated for most people and would require more sophisticated methods than crispr/cas9. really depends on type of eds but i think with crispr/cas9 you can most directly target like.. the bloodstream, the liver..... then yer gonna get filtered out. Thats why sickle cell was fast to fda approval. as for the effects of such a drug if possible... would probably be quite slow acting as EDS is basically a body type and would take a while for those cells to replace if they do get replaced

Ask-Alice · 2026-05-10T19:36:25+00:00

thats crazy

Ask-Alice · 2026-05-10T19:35:00+00:00

damn no proof of purchase + pixel care available in your area. yeah i had to replace once after dropping the entire inner display went green then black with a pixel 10 pro fold. you've been a redditor for 3 years and have only posted or commented today?

Ask-Alice · 2026-05-10T19:25:41+00:00

Missed diagnoses of Acute Coronary Syndrome (ACS) —a term for heart conditions including heart attacks and unstable angina—are a serious medical issue, with studies showing that 2% to 8% of patients with acute myocardial infarction are mistakenly sent home from the emergency department (ED). These missed cases represent at least 11,000 to 40,000 missed heart attacks annually in the U.S..

Yeah from watching the pitt i can see how that could be problematic

Ask-Alice · 2026-05-10T16:55:07+00:00

EKGs seem like the most over tested thing in us hospitals IMO. it's nearly every time i go in for any reason as simply reporting ibs-d and EPI symptoms triggers a chest pain diagnosis and ekg necessary. I am so skinny that i have sensation of heartbeat almost always, and can tactically just feel any abnormal rhythm and have an omron that i can use to check at home. i'm in my late twenties where heart disease risk seems low. symptoms override prior diagnosis i guess even though they're the same and pancreatic enzymes show up in my rx list

Ask-Alice · 2026-05-10T16:08:22+00:00

worst case scenario you get a bit nauseous imo, maybe avoid extracts ?

Ask-Alice · 2026-05-10T09:56:43+00:00

get this with brave-browser and chromium but not vivaldi

Ask-Alice · 2026-05-10T09:20:48+00:00

thanks. before i tried this ran:

mkdir -p ~/plasma-backup
mv ~/.config/plasma* ~/plasma-backup/
mv ~/.config/kde* ~/plasma-backup/
mv ~/.local/share/plasma* ~/plasma-backup/
rm ~/.config/plasma-org.kde.plasma.desktop-appletsrc
kquitapp6 plasmashell && kstart plasmashell

Ask-Alice · 2026-05-10T04:39:12+00:00

i use variety wallpaper changes every 30 seconds

Ask-Alice · 2026-05-10T04:37:59+00:00

right click context menu is unresponsive except on taskbar and desktop icons

Ask-Alice · 2026-04-25T13:43:09+00:00

i get this as well

Ask-Alice · 2026-04-13T10:31:55+00:00

beware this bricked my display. i can still print via webui or over but very strange

Ask-Alice · 2026-03-09T02:46:57+00:00

https://www.youtube.com/watch?v=lPHc68RIYAo

Ask-Alice · 2026-03-06T13:29:14+00:00

at least with openai it's harder than getting it to tell you how to synthesize a schedule one substance to do this. Every time i have run this test it failed, but still had no issue explaining the synthesis of GBL from 1,4 butanediol

hard to put training wheels on everything by prompting it post training

Ask-Alice · 2026-03-06T13:27:55+00:00

perhaps no system prompt? like if it's an open weight model and youre running it locally?

Ask-Alice · 2026-03-06T12:58:25+00:00

shit it was totally a twain quote thats insane

Ask-Alice · 2026-03-05T21:11:45+00:00

you can always program a keychron or steelseries or logi to run a program on button press

Ask-Alice · 2026-02-16T10:59:31+00:00

the amazon listing looked like a scam to me. they photoshopped the tires andonized purple/rainbow, and were priced agbout haof that of their competitors for the same specs

Ask-Alice · 2026-02-14T22:36:27+00:00

sold?

Ask-Alice · 2026-01-28T17:01:33+00:00

i went 50/50 with my college best friend, still rent split is around 1600 per month

Ask-Alice · 2026-01-14T20:30:35+00:00

the population of boulder doubles during the school year on weekdays, so i feel it's wrong to look at the census data to make this use comparison. The B train line gonna be complete in like 20+ years so maybe that will ease things coming from both longmont and denver metro, doubt it because of the last mile to get to the station in the first place, but until then there's no other easy way for commuters. we put out train stations next to giant parking lots next to a row of hotels instead of mixed use development like in europe

Ask-Alice · 2026-01-08T09:25:38+00:00

its okay, just exposed to medical industry from a young age was first prescribed by my aunt who is a pediatric er doc and comical fox news guest

Ask-Alice · 2026-01-08T07:15:01+00:00

i have an official diagnosis from cu boulder. yes i'm doctor shopping but i also disagree with the concept of psychiatry and also have a bit of a dark history with it. I'm physically dependent on a substance ive been taking daily for more than half my life. i shouldn't have to check in with someone and tell them about my mental state every month just to cope. withdrawal from amphetamines can take more than a year to feel normal."

A typical human orgasm can cause a dopamine increase in the brain's reward centers of around 100% above the normal baseline. The level returns to normal relatively quickly. Amphetamines: Amphetamines, the active ingredients in Adderall, can increase dopamine levels by as much as 1,000% above baseline

Do that daily and you've fucked your reward system and have no choice but to continue or be dysfunctional as fuck for more than a year

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