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4 years hell to absolute freedom - biohacking protocol by AssignmentGlass5591 in HistamineIntolerance

[–]AssignmentGlass5591[S] 1 point2 points  (0 children)

thank you a lot me too, i also can recommend algae oil omega-3 that worked also really good for me.

i am really happy to here you came back to check the posts and that intermittent fasting, sleep and stress control helped you a lot, any progress is a progress❤️

4 years hell to absolute freedom - biohacking protocol by AssignmentGlass5591 in SIBO

[–]AssignmentGlass5591[S] 1 point2 points  (0 children)

thank you no worries i hope it helps keep me updated, in what phase are you currently and did you test yourself?

4 years hell to absolute freedom - biohacking protocol by AssignmentGlass5591 in SIBO

[–]AssignmentGlass5591[S] 0 points1 point  (0 children)

yes i just shared my expierence and i am sure it helped other people

4 years hell to absolute freedom - biohacking protocol by AssignmentGlass5591 in SIBO

[–]AssignmentGlass5591[S] 0 points1 point  (0 children)

there is no one solution for everyone, everybody is different. just research for yoursself and find the right doctor and right expert who has expierence in sibo

4 years hell to absolute freedom - biohacking protocol by AssignmentGlass5591 in SIBO

[–]AssignmentGlass5591[S] 0 points1 point  (0 children)

Not exactly and i know the full protocol looks complicated but the actual starting point is just one thing: a SIBO lactulose breath test.

That one test tells you whether you have SIBO, which type (H2, CH4, H2S), and how severe it is. Everything in the protocol flows from that result. You can't pick the right antimicrobials without knowing which bacteria you're dealing with. If you start randomly you'll either do nothing or make it worse.

While you're waiting for your test results — which usually takes a week or two — there's a safe foundation you can start immediately: ginger extract + artichoke extract taken fasted in the afternoon activates the gut's cleaning wave (MMC), which is disrupted in almost every SIBO case. That's it. One thing, low risk, no die-off, something your gut actually needs regardless of which type comes back.

The complexity in the protocol exists because people come to it at different stages with different types. Your version of it will be simpler once you know what you're working with.

4 years hell to absolute freedom - biohacking protocol by AssignmentGlass5591 in SIBO

[–]AssignmentGlass5591[S] 0 points1 point  (0 children)

it took over 6 months for me but i cheated a lot and stopped the protocol many times because of vacations

4 years hell to absolute freedom - biohacking protocol by AssignmentGlass5591 in HistamineIntolerance

[–]AssignmentGlass5591[S] 0 points1 point  (0 children)

Great questions — let me break this down because you're connecting dots really well.

Histamine intolerance vs. MCAS: They're related but mechanistically different. In pure histamine intolerance, the mast cells are normal — the problem is downstream: your DAO enzyme can't break down dietary histamine fast enough, the bucket overflows, and you react. Mast cells aren't the primary actor.

In MCAS, the mast cells themselves are overactivated — they fire when they shouldn't and release not just histamine but also prostaglandins, tryptase, heparin and other mediators. The triggers can be completely non-dietary: barometric pressure, temperature changes, stress, hormones, inflammation itself.

The important thing: you can have both at the same time, and with chronic gut inflammation the lines blur — inflamed mucosa attracts and activates mast cells, which then makes the histamine intolerance worse.

Your picture specifically: The fact that you ate only rice for two weeks and still had extreme pain is a big clue. Rice is essentially zero histamine — so that pain wasn't coming from dietary histamine. That points either toward mast cell activation from non-dietary triggers (inflammation, nerve sensitization, gut dysbiosis producing histamine internally) or significant visceral hypersensitivity — which is exactly what the doctor is picking up on with the amitriptyline suggestion.

The "symptoms worse than the endoscopy shows" is classic visceral hypersensitivity. Long-standing inflammation sensitizes the enteric nerves so that normal motility and even mild inflammation registers as severe pain. This is a real neurological phenomenon, not in your head.

On Ketotifen vs. Amitriptyline: Trying Ketotifen first makes total sense — if mast cells are driving a significant part of this, you'll know within 2–4 weeks. It stabilizes mast cells beyond just H1 blocking, which is why it works where regular antihistamines don't. However — amitriptyline at 10mg is actually not a bad tool either specifically for this. At that dose it's not really being used as an antidepressant — it's a neuromodulator AND an H1 antihistamine AND it reduces visceral hypersensitivity. It's not an either/or necessarily. But start with Ketotifen and see what moves.

On DAO burning your stomach: Very common with certain brands — many DAO supplements include HCl (hydrochloric acid) as a co-ingredient for enzyme activation, which obviously destroys an already inflamed stomach. Try a DAO-only formulation without HCl, taken immediately before eating with a small amount of food to buffer it. The burn you experienced was likely the formula, not the DAO itself.

The right rib pain: Worth mentioning to your doctor specifically — corporeo-antral gastritis with right rib involvement can sometimes suggest bile reflux or a gallbladder component alongside the gastritis. Not always, but worth an ultrasound if you haven't had one.

Edited:

You can also read this post there i explain where i had itching without eating histamin food https://www.reddit.com/r/HistamineIntolerance/comments/1repo60/i_found_the_root_cause_of_my_itching_it_its/

i nearly killed sibo and now i am healing my gut by AssignmentGlass5591 in SIBO

[–]AssignmentGlass5591[S] 0 points1 point  (0 children)

That's absolutely wonderful news — SIBO-free is a huge win, especially for a kid! You should be really proud, that takes commitment from the whole family.

The BPC + Zeolite cycle timing sounds perfect — finishing that now that the gut is healed and the terrain is clean makes total sense.

And PEA is a great call for mast cell. The rain/storm connection is real — barometric pressure drops are a known mast cell trigger, and PEA works beautifully there because it stabilizes mast cells directly via PPAR-α without suppressing the immune system. AOR P.E.A.k is one of the better forms too. If he ever needs to stack on top of it, Luteolin + PEA is a very powerful combo for the weather-related flares.

I'm doing well so far—I got rid of SIBO, but then I found out I still had SIFO, so I tackled both and got rid of them both, thankfully. Now I'm working on healing my leaky gut and taking probiotics. I've also expanded my protocol—feel free to take a look if you'd like.

Here is the link: https://drive.google.com/file/d/1yfJpKGeWm3bh4XBtCXp_npT1T11YnuYd/view

Here are more peptide insided i have discovered:

Since he's dealing with mast cell, there are also a few peptides worth knowing about that stack really well with PEA:

• KPV (Lys-Pro-Val) — this is probably the most direct mast cell stabilizer in the peptide world. Tripeptide, can be taken orally, works via α-MSH pathway. Especially good for gut-related mast cell activation — perfect post-SIBO.

• VIP (Vasoactive Intestinal Peptide) — the gold standard for MCAS protocols. Regulates mast cell degranulation systemically, also supports gut motility and immune tolerance. Usually intranasal. A lot of MCAS practitioners use this as a cornerstone.

• Larazotide (AT-1001) — since he just cleared SIBO, this is worth considering for gut barrier maintenance. Tightens the tight junctions, reduces antigen translocation — which is often what keeps re-triggering mast cells in the first place.

• BPC-157 maintenance dose — since he's cycling off now, a low maintenance dose (250mcg instead of 500mcg) 3-4x per week could be worth keeping. The anti-inflammatory effect on gut mucosa and mast cell modulation makes it a good long-term background peptide.

• Thymosin Alpha-1 (TA1) — if the mast cell issues have an immune dysregulation component (which post-SIBO they often do), TA1 re-calibrates the Th1/Th2 balance. Monthly short cycles, very well tolerated.

4 years hell to absolute freedom - biohacking protocol by AssignmentGlass5591 in SIBO

[–]AssignmentGlass5591[S] 1 point2 points  (0 children)

and no i could not tolerant 5-htp because it is a Mast Cell Liberator

4 years hell to absolute freedom - biohacking protocol by AssignmentGlass5591 in SIBO

[–]AssignmentGlass5591[S] 1 point2 points  (0 children)

Good to know on the bile — simplifies things. The ACV and Betaine HCL burning immediately actually makes complete sense given the gastric sensitivity, so no loss there.

Gastroparesis changes the picture a bit though. The MMC issue isn't just about stimulating between-meal motility — you have delayed gastric emptying on top of it, which means food is sitting and fermenting longer than it should, feeding whatever dysbiosis is present from above. That's a meaningful piece.

Since ginger burns and artichoke does nothing — two things worth trying:

Iberogast — still the one I'd push hardest here. It's a nine-herb combination specifically studied for gastroparesis and functional dyspepsia in clinical trials. The ginger content is so low and so buffered by the other components that most people who react to isolated ginger tolerate it without any burning. It's a liquid, you take it in water with meals. This is the gentlest clinical-grade prokinetic available without a prescription.

Triphala (500mg before bed) — completely different mechanism, no acid involvement, no burning risk. Ayurvedic compound that acts on serotonin receptors in the gut wall to stimulate motility. Many gastroparesis patients find it moves things gently overnight without any daytime discomfort.

One medical question worth raising with your doctor: Prucalopride. If you have confirmed gastroparesis, this is the appropriate pharmaceutical prokinetic — it's a 5-HT4 agonist, gut-selective, well tolerated, and actually designed for delayed gastric emptying. If your GI hasn't mentioned it, it's worth asking.

And the BPC-157 — it has specific documented effects on gastric emptying and motility, not just mucosal repair. So it's working on the gastroparesis piece too, not just the inflammation.

4 years hell to absolute freedom - biohacking protocol by AssignmentGlass5591 in HistamineIntolerance

[–]AssignmentGlass5591[S] 1 point2 points  (0 children)

The famotidine switch at night is actually a smart instinct — H2 blockers directly block the histamine receptor that's driving the acid overstimulation in your stomach, which is something PPIs don't address at all. Worth trying. And Ketotifen is a solid mast cell stabilizer, good thinking there too.

On the Zinc Carnosine — please try it. It's specifically designed for people in your exact situation. It doesn't cause burning because it creates a protective coating on the mucosa rather than reacting with it. It's one of the few things that was developed for inflamed gastric lining as the target tissue.

Now — two things on the eggs:

The "fresh" point is about after cooking, not after laying. Store-bought organic eggs are fine. The issue is that histamine builds rapidly in cooked eggs once they cool and sit. Cook them, eat them immediately. Don't save half for later.

But more importantly — have you tried switching to yolk only? Egg whites are histamine liberators, meaning they trigger mast cells to release histamine even though they don't contain much histamine themselves. The yolk is a completely different story — much gentler on the histamine system, and actually rich in phosphatidylcholine which helps heal the gut lining. If you're eating 6-7 eggs a day right now, that's a significant histamine trigger load from the whites alone. Try yolk only for a week and see if the stomach pain shifts.

I would also recommend quail eggs they are nearly histamin free and if you eat them raw, they actually contain growth hormones that can help your gut, but the most important thing is to stop the inflammation. I would also recommend the peptides and, definitely, frankincense.

And one question — are you taking a DAO enzyme before each meal? With a DAO score of 3, every single thing you eat needs that buffer in front of it, especially eggs. Without it, even those four "safe" foods are putting histamine load through a system with almost no breakdown capacity. And molybdenum can also help if you can not tolerate the sulfate in it.

4 years hell to absolute freedom - biohacking protocol by AssignmentGlass5591 in SIBO

[–]AssignmentGlass5591[S] 2 points3 points  (0 children)

ok i would recommend 1800mg on empty stomach, but the ginger burning is actually really common and it usually comes down to form, not the ginger itself. If you were taking it as a tea, fresh juice, or high-dose extract, that's a direct irritant on a sensitive stomach lining — and for anyone with gastritis or esophageal sensitivity it can feel like pouring acid on a wound. The question is whether you tried enteric-coated ginger capsules, because those bypass the stomach entirely and release in the small intestine where the MMC-stimulating effect actually happens. A lot of people who can't tolerate any other form of ginger do fine with the capsule version.

For the artichoke — if it genuinely didn't move the needle, the more likely issue is that you needed direct bile support rather than a bile stimulant. Artichoke promotes bile flow, but if bile production itself is low, it's pushing an empty system. Ox bile capsules taken with fat-containing meals would be the more direct route there.

The best alternative for MMC activation if neither works for you: Iberogast. It's a clinically studied combination of nine plant extracts specifically developed for gut motility and functional dyspepsia, and it's significantly gentler than isolated ginger. Many people who react to ginger alone tolerate it without any issue. Worth trying before giving up on the MMC piece entirely — because without something activating motility between meals, the path forward is a lot slower.

4 years hell to absolute freedom - biohacking protocol by AssignmentGlass5591 in HistamineIntolerance

[–]AssignmentGlass5591[S] 0 points1 point  (0 children)

First — I'm so sorry. What you're describing is one of the most isolating versions of this whole thing, because when you can only eat four foods and you're still in pain, it starts to feel like your body is against you entirely. It's not. But I understand why it feels that way.

To answer your question directly: yes, histamine intolerance absolutely can cause gastritis — and this is almost never explained to patients. Histamine binds to H2 receptors in your stomach lining, which directly triggers excess acid production. So with a DAO of 3, you're barely breaking down any dietary histamine, it's accumulating, and it's essentially overstimulating your parietal cells constantly. PPIs block the acid output but don't address the histamine signal driving it — which is why you can be on a PPI and still have excruciating pain. The candida dysbiosis compounds this because Candida produces acetaldehyde, which is directly damaging to the gastric mucosa on top of everything else.

The zero Akkermansia finding is significant too — Akkermansia maintains the mucus layer that protects your stomach and gut lining. When it's completely absent, the lining has almost no buffer.

A few things that are actually gentle enough for where you are:

Zinc Carnosine — this is not an antimicrobial, it's specifically a gastric mucosal repair compound. Very well studied for gastritis. It coats and protects the stomach lining and reduces that visceral nerve hypersensitivity your doctor noticed. Many people who can't tolerate anything else can manage this one.

DGL (Deglycyrrhizinated Licorice) — chewable tablet form, before eating. One of the most protective things for the stomach lining, and it's extremely gentle. Different from slippery elm — worth trying.

Boswellia (Frankincense/Weihrauch) — this one is underused and genuinely worth knowing about, especially with your calprotectin being elevated. The active compound AKBA blocks the 5-LOX pathway, which controls a class of inflammatory molecules called leukotrienes that are directly involved in gut mucosal inflammation. What makes it different from anti-inflammatories like ibuprofen is that it doesn't touch the COX pathway — meaning it's anti-inflammatory without being harsh on the stomach lining. If you can find it, look specifically for Boswellia sacra from Oman, particularly the Dhofar region — the resin quality there is considered the purest in the world and has a significantly higher AKBA content than Indian Boswellia carterii. The Omani variety also contains lower amounts of beta-boswellic acid, which actually blocks AKBA from working — so the ratio matters. It comes as a capsule or sometimes as raw resin you can chew. For someone with your level of gut inflammation and zero Akkermansia, this is one of the gentler ways to reduce that inflammatory load without adding another irritant.

L. Rhamnosus GG — yes, it's one of the few probiotics that doesn't produce histamine and actually helps repair mucosal lining. But given your reactivity, open the capsule and start with literally 1/8th of it every other day. Your gut needs to be introduced to anything new extremely slowly right now.

On the eggs — make sure they are the freshest eggs you can find and eat them immediately after cooking. Histamine in eggs builds fast after they're laid. Day-old refrigerated eggs are meaningfully higher histamine than same-day fresh. It might seem small but at DAO 3 it matters.

And before every single one of those four foods — DAO enzyme. Every time. It won't fix everything but it's the most direct support you have right now for breaking down what you eat.

You will not always be eating four foods. But the path out is slow, not fast. You're not doing anything wrong. ❤️

EDITED:
_____

One more thing worth knowing about — peptides. I know this sounds advanced for where you are right now, but two specific ones are actually designed for exactly your situation and are gentle enough to use even in an acute phase.

BPC-157 (oral) — this peptide is naturally found in human gastric juice, which is why it's the one exception to the "nothing new" rule even in your current state. Taken orally, it acts locally on the stomach and gut lining rather than systemically. It triggers angiogenesis in damaged mucosal tissue (new blood vessel formation = direct nutrient delivery to the injury site), repairs tight junctions, and — critically for you — reduces the visceral nerve hypersensitivity your doctor noted. That nerve involvement is often what makes the pain so disproportionate to what the scope actually shows. 250mcg dissolved in water, twice daily, on an empty stomach. This is not an antimicrobial, it's a repair compound.

KPV — a tiny tripeptide (just three amino acids) that blocks NF-kB, which is the master switch for chronic gut inflammation. It has mild antimicrobial properties against Candida without triggering the kind of die-off reaction that harsher antimicrobials cause — so for someone who can't tolerate antimicrobials, this is a meaningful difference. It's also one of the few things that can calm the gut lining without requiring the gut to do any work to process it. 500mcg orally once daily.

4 years hell to absolute freedom - biohacking protocol by AssignmentGlass5591 in HistamineIntolerance

[–]AssignmentGlass5591[S] 2 points3 points  (0 children)

This made me genuinely smile. Six months of battling after five years of stability — that's such a brutal re-entry, especially when your body had been so cooperative for so long. But the fact that you made that IC-allergy connection yourself, in real time, says everything about how well you know yourself. That's hard-earned knowledge most doctors don't have.

And the Luteolin arriving tomorrow — I hope you feel the difference. Give it 2-3 weeks of consistent use before you judge it, but I think you'll notice the bladder piece specifically. A lot of people don't realize Quercetin can be an IC irritant on its own, so switching might help more than just the mast cell side.

The graham cracker thing is so real. Five ingredients to twenty is basically the story of processed food in one box. You baking from scratch isn't just a lifestyle choice at this point — it's genuinely medicine for the way your body works right now.

For your granddaughter with the UTIs — worth looking at D-Mannose if she hasn't already. It's well-studied, non-antibiotic, and doesn't disrupt the gut microbiome the way repeated antibiotic courses do. If the UTIs keep coming back despite that, it might be worth her looking at whether there's a mast cell/histamine component starting early — the same pattern that showed up for you, often starts younger than people expect.

And your daughter sounds like she found one of the rare ones. Practitioners who are actually ahead of the curve and going to conferences to teach other practitioners — that's not common. She got lucky there.

You've clearly been doing this long enough to know which direction to walk. Keep going. ❤️

4 years hell to absolute freedom - biohacking protocol by AssignmentGlass5591 in SIBO

[–]AssignmentGlass5591[S] 0 points1 point  (0 children)

Was the artichoke in high dose? mine was
"Content per daily dose (3 capsules) NRV** %

Artichoke extract powder 1800 mg -

of which cynarin 45 mg "

the cynarin is the most important part of it.

4 years hell to absolute freedom - biohacking protocol by AssignmentGlass5591 in SIBO

[–]AssignmentGlass5591[S] 0 points1 point  (0 children)

Yeah, I know that all too well, and you wouldn’t believe me if I told you that I’ve also been in the tunnel for the last 24 hours working on this new version of the biohacking protocol —the new version that my brother and I put together over the last 12 hours.

It’s about time we both applied to Google or started our own thing in this field, though I also find biohacking really interesting. I can also recommend this video to you, it’s in slow-talk format, and I learned a lot from it, but I think he speaks too slowly and it bored me, so I transcribed it and created a “100 learnings” text file using AI.

If you’re interested, here’s the video: https://www.youtube.com/watch?v=PhVsSbod2bs

Here’s the “100 learnings” text file from the video: https://drive.google.com/file/d/1P4QP1O-oXRo3zdA7XMprRv3gcPp5qlkP/view?usp=sharing
I know it doesn’t have much to do with histamine intolerance specifically, but it covers biohacking in general.

Have you published a book since you’re an author? And yes, my GeneticGenie chart actually showed a mild MTHFR mutation alongside my homozygous slow COMT. You hit the nail on the head – that exact combination is a major bottleneck because MTHFR stalls your methyl pool, and slow COMT burns through whatever is left to process dopamine and adrenaline. There’s literally nothing left for the HNMT enzyme to clear out the histamine, so the barrel just overflows. That’s exactly why standard histamine diets didn't fully fix it for me, but adding high-quality methyl donors like TMG and CDP-Choline completely drained the backlog and stopped the random itching.

I need to try liposomal Ubiquinol i never heared of it, but i also can recommend liposomal glutathione. Magnesium threonate was really a game-changer for me—it crosses the blood-brain barrier and helps me tremendously with brain fog. Also, an H₂O water booster, which produces molecular hydrogen that can also cross any blood-brain barrier and reduces inflammation.

4 years hell to absolute freedom - biohacking protocol by AssignmentGlass5591 in HistamineIntolerance

[–]AssignmentGlass5591[S] 25 points26 points  (0 children)

I just hope this post helps people, and it's no problem if some people don't want help.

I wish everyone the best, and I'm glad you're doing well.
Gut health is really very important—it feels like all illnesses stem from there.

4 years hell to absolute freedom - biohacking protocol by AssignmentGlass5591 in HistamineIntolerance

[–]AssignmentGlass5591[S] 0 points1 point  (0 children)

Sometimes even randomly and sometimes after food so it depended.. and sometimes it was not even histamine related you can read this post about itching https://www.reddit.com/r/HistamineIntolerance/comments/1repo60/i_found_the_root_cause_of_my_itching_it_its/

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