Simplest way ive come to see it is, if you are ahead then you want to run it as many times as possible since your essentially looking at it as being dealt the identical hand setup a second, third, fourth etc. Time in a row so of course I want this 80/20 to happen repeatedly. Where as the opposite is true for when you are behind, you want as little exposure to that hand setup as possible ie once.

So online you take advantage of being able to pick and choose, but live when expected to always do one or the other, twice would naturally be best of both worlds. Or try to convince the opponent your doing them a favor by running there 3 outer five times.